ABO blood type and ABO gene with susceptibility to deep vein thrombosis following orthopedic surgery: a casecontrol study in Chinese Han population  

作　　者：SUN Ye MAO Ping LU JingWei DAI Jin TENG HuaJian JIANG Qing 

机构地区：[1]The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University [2]Joint Research Center for Bone and Joint Disease, Model Animal Research Center, Nanjing University

出　　处：《Science China(Life Sciences)》2015年第4期390-391,共2页中国科学（生命科学英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(30973046);China National Funds for Distinguished Young Scientists(81125013)

摘　　要：The ABO gene encodes a glycosyltransferase with three main alleles （A, B, and O）. The ABO blood group molecules are expressed in varieties of human tissues. Individuals with type O blood group have about 25% lower plasma FVIII and VWF levels [1]. Increased plasma FVIII and VWF levels are associated with an increased risk for VTE, and non-O blood group type is associated with an increased VTE risk which is independent of FVIII [2]. Yet the risk of ABO blood group type has not been studied in Asian population. In a genome-wide association study and subsequent replication studies, two single-nucleotide polymorphisms （SNPs） in ABO, rs657152 and rs505922 were associated with VTE [3]. However, there has been no study regarding the association between ABO gene and acute deep vein thrombosis （DVT） in Chinese population. We hypothesized that ABO blood type and ABO gene associated with acute DVT after orthopedic surgery and carried out a case-control study in patients after orthopedic surgery in Han Chinese population.The ABO gene encodes a glycosyltransferase with three main alleles(A,B,and O).The ABO blood group molecules are expressed in varieties of human tissues.Individuals with type O blood group have about 25%lower plasma FVIII and VWF levels[1].Increased plasma FVIII and VWF levels are associated with an increased risk for VTE,

关 键 词：ABO血型 中国汉族人群 静脉血栓 等位基因 骨科手术 血栓形成 病例 易感性 

分 类 号：R687.3[医药卫生—骨科学]