通灵养心方干预前临床心力衰竭阶段左室重构的疗效观察  

Efficacy of Tongling Yangxin Decoction on Ventricular Remodeling in Patients with Pre-clinical Heart Failure

作　　者：裴雯 董耀荣[2] 

机构地区：[1]上海市闸北区中医医院,上海200072 [2]上海市中医医院

出　　处：《中西医结合心脑血管病杂志》2015年第3期287-289,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：上海市第三批上海市中医临床优势专科(专病)建设项目(No.ZYSNXD-YL-YSZK027)

摘　　要：目的观察通灵养心方干预前临床心力衰竭阶段心室重构的效果。方法选择符合前临床心衰阶段诊断标准,且属于中医气阴两虚证型患者61例。随机分为治疗组与对照组。对照组在控制危险因素和积极治疗高危人群原发病基础上,使用血管紧张素转换酶抑制剂(ACEI)或血管紧张素Ⅱ受体拮抗剂(ARB)以及β受体阻滞剂(无禁忌证)。治疗组在对照组治疗基础上加用通灵养心方,均观察治疗6个月。治疗期间记录两组患者的左室舒张末期内径(LVDd)、左室收缩末期内径(LVDs)、室间隔厚度(IVS)、左室射血分数(LVEF)、左室后壁厚度(PWD)、左室心肌质量指数(LVMI)。结果治疗组治疗后LVDd,LVDs,IVS,PWD,LVMI较治疗前明显改善(P<0.01),对照组仅LVDd改善明显(P<0.05),两组LVDd比较有统计学意义(P<0.05);对照组对男性LVMI有改善((P<0.01),两组LVMI比较有统计学意义(P<0.05),对照组对女性LVMI改善不明显。结论通灵养心方对气阴两虚的前临床心衰阶段,具有抑制心室重构的作用,对延缓心衰发生有益。Objective To investigate the effect of Tongling Yangxin decoction（TYD）on ventricular remodeling in patients with preclinical heart failure.Methods Sixty-one patients with pre-clinical heart failure and deficiency syndrome of qi and yin were randomly divided into two groups：The control group treated with routine treatment（preventing risk factors and treating the original disease with angiotensin converting enzyme inhibitor or angiotomin II receptor antagonist andβacceptor block agent without contraindication）,and the treatment group treated with routine treatment plus TYD for 6 months.The change of UCG were observed during the course.Results After treatment,left ventricular diastolic diameter（LVDd）,left ventricular systolic diameter（LVDs）,inter-ventricular septum（IVS）,PWD,left ventricular mass index（LVMI）were improved in treatment group（P〈0.01）.There was statistical significance in LVDd and LVMI between two groups（P〈0.05）.Conclusion TYD has a good effect on the pre-clinical heart failure,which can improve the ventricular remodeling.

关 键 词：前临床心衰阶段 通灵养心方 心室重构 

分 类 号：R259[医药卫生—中西医结合]