热休克蛋白70与急性心肌梗死后心室重构的关系  

Relation between heat shock protein 70 and ventricular remodeling after acute myocardial infarction

作　　者：周纪星 

机构地区：[1]山东省沂水中心医院心内科,276400

出　　处：《中国实用医药》2015年第6期41-42,共2页China Practical Medicine

摘　　要：目的探讨热休克蛋白70(HSP70)与急性心肌梗死(AMI)后心室重构的相关性。方法 78例急性心肌梗死患者,根据6个月后左室舒张末期容积指数是否较基线值增加20%将其分为左室重构(LVR)组和非左室重构(NLVR)组。入院后第2天清晨空腹测静脉血中的HSP70,发病第3天和6个月分别行心脏超声心动图测定左室舒张末期容积(LVEDV)。结果 LVR组中HSP70水平高于NLVR组,差异具有统计学意义(P<0.05),LVR组中HSP70水平与LVEDV呈正相关(P<0.05)。结论 AMI后HSP70的表达参与了左室重构的发生,对左室重构有一定的预测价值。Objective To investigate the correlation between heat shock protein 70（HSP70） and ventricular remodeling after acute myocardial infarction（AMI）. Methods A total of 78 patients with AMI were divided into left ventricular remodeling（LVR） group and non left ventricular remodeling（NLVR） group, according to whether their LVEDV was increased 20% more than basic level after 6 months. Their levels of HSP70 were detected in venous blood in the second morning of admission. Ultrasonic cardiography was applied for detection of left ventricular end diastolic volume（LVEDV） on the third day and the sixth month of disease. Results The LVR group had higher HSP70 level than the NLVR group, and the difference had statistical significance（P〈0.05）. HSP70 level was positively correlated with LVEDV in the LVR group（P〈0.05）. Conclusion Expression of HSP70 is involved in the occurrence of LVR after AMI, and it has a certain value in prediction for LVR.

关 键 词：热休克蛋白70 急性心肌梗死 左室重构 

分 类 号：R542.22[医药卫生—心血管疾病]