改性海藻酸钠聚集行为对电纺纳米纤维形貌的影响  

Effect of Modified Sodium Alginate Aggregation Behavior on Electrospun Nanofiber Morphology

作　　者：高鹏博[1] 冯玉红[1] 李嘉诚[1] 颜慧琼[2] 黄俊浩[1] 武田田[1] 黄文红[1] 

机构地区：[1]海南大学材料与化工学院,海口570228 [2]海南师范大学化学化工学院,海口571158

出　　处：《高等学校化学学报》2015年第4期799-807,共9页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21366010);海南省重点科技计划(批准号:ZDXM2014037;ZDXM20120003);海口市重点科技计划项目(批准号:2014055);海南省自然科学基金(批准号:214017);海南省水环境污染治理与资源化重点实验室开放基金资助~~

摘　　要：以过硫酸钾(KPS)为引发剂,采用双丙酮丙烯酰胺(DAA)对海藻酸钠(SA)进行改性,制备了海藻酸钠-聚双丙酮丙烯酰胺两亲性共聚物(SA-PDAA).将SA-PDAA与聚乙烯醇(PVA)复配,并进行静电纺丝,制得SA-PDAA/PVA电纺纳米纤维.通过红外光谱、差示扫描量热和荧光光谱表征了SA-PDAA的结构和性能,通过黏度仪、表面张力仪和电导率仪测试了SA-PDAA纺丝液的物理性能,用扫描电子显微镜表征了SA-PDAA/PVA电纺纳米纤维的形貌,考察了SA-PDAA/PVA电纺纳米纤维的释药性能.结果表明,DAA接枝到SA分子链上,SA-PDAA的临界聚集浓度为0.072 g/L,SA-PDAA具有良好的两亲性,SA-PDAA/PVA电纺纳米纤维具有均一的形貌.改性后的SA可以有效地减缓药物释放速度,提高SA-PDAA/PVA电纺纳米纤维的缓释性能.Using the potassium persulfate（ KPS） as an initiator,through modified reaction of diacetone acrylamide（ DAA） and sodium alginate（ SA）,the amphiphilic SA-PDAA block copolymer was synthesized. By electrospinning the mixture of SA-PDAA and polyvinyl alcohol（ PVA） solution,SA-PDAA / PVA electrospun fibers were prepared. The structure and properties of SA-PDAA were characterized by means of Fourier transform infrared spectroscopy（ FTIR）,differential scanning calorimetry（ DSC） and fluorescence spectrum. Furthermore. The physical properties of SA-PDAA spinning solution were determined by viscometer,surface tensiometer and electrical conductivity meter,the morphology of SA-PDAAA / PVA electrospun fibers were determined by scanning electron microscopy（ SEM）. And the drug release studies of SA-PDAAA / PVA electrospun fibers were also investigated. Experimental results showed that DAA had successfully grafted onto the sodium alginate molecular chains. The critical aggregation concentration measured by fluorescence spectrum was reduced to 0. 072 g / L,which demonstrated the good amphipathy of SA-PDAA. The morphology of SA-PDAA /PVA electrospun fiber exhibited more uniform size. The drug release properties show that SA-PDAA can effectively slow the drug release rate,thus improving the retarded releasing characteristics of SA-PDAA / PVA electrospun fibers.

关 键 词：改性海藻酸钠 聚乙烯醇 静电纺丝 纳米纤维 双丙酮丙烯酰胺 

分 类 号：O631.3[理学—高分子化学] O631.4[理学—化学]