胰岛素原稳态与胰岛β细胞功能  

Proinsulin homeostasis and islet β cell function

作　　者：朱丹[1] 蔡可英[2] 曹萌[3] 刘超[3] 

机构地区：[1] 徐州医学院,221004 [2] 徐州医学院第二附属医院内分泌科,221006 [3] 南京中医药大学附属中西医结合医院内分泌代谢病院区,210028

出　　处：《国际内分泌代谢杂志》2015年第2期110-113,共4页International Journal of Endocrinology and Metabolism

摘　　要：胰岛β细胞内质网中有大量新合成的胰岛素及胰岛素前体即胰岛素原,胰岛素原经过正确的处理转换为天然折叠单体形式即有活性的胰岛素原,后者经过剪切去除C肽而形成胰岛素,从而发挥生物学效应.未折叠或者错误折叠的胰岛素原则仍以非天然折叠多肽的形式存在于内质网中.任何原因导致的胰岛素原折叠率的改变均会导致胰岛素原稳态失衡,导致内质网应激和胰岛β细胞的功能改变.There is a large number of newly synthetic insulin and proinsulin in endoplasmic reticulum of islet [β cells.If correctly folded,proinsulin can be converted into native folded monomeric proinsulin with activity.Unfolded or misfolded non-native form of proinsulin will be preserved in the endoplasmic reticulum as the folded polypeptide.Changes of proinsulin folding rate caused by any reasons will result in the imbalance of proinsulin homeostasis,endoplasmic reticulum stress and islet [β cells dysfunction.

关 键 词：胰岛素原 胰岛Β细胞 糖尿病 胰岛素原稳态 

分 类 号：R587.1[医药卫生—内分泌]