不同类型干细胞在心肌组织工程中的应用及进展  

The application and development of different stem cell in cardiac tissue engineering

作　　者：李森[1] 叶晓峰[1] 龚文辉[1] 赵强[1] 

机构地区：[1]上海交通大学瑞金医院心外科,上海200025

出　　处：《临床与病理杂志》2015年第3期490-494,共5页Journal of Clinical and Pathological Research

基　　金：国家自然科学基金(81000096)~~

摘　　要：慢性缺血性心脏病多由冠状动脉粥样硬化引起,目前治疗上较为棘手。近年来,心肌组织工程的发展为此疾病的治疗带来了曙光。心肌组织工程主要包括种子细胞的获取、支架材料的研制、以及心肌组织的构建三部分。种子细胞的来源和种类则是心肌组织工程中的关键环节。我们总结近年来干细胞研究的进展,对研究较多的几种干细胞在心肌组织工程中的应用作一综述,这些干细胞包括:心脏祖细胞,胚胎干细胞,间充质干细胞,诱导多能干细胞,以及用于构建心肌再生的内皮祖细胞等,并对未来干细胞的发展作一展望。Usually, chronic ischemic cardiac disease is caused by coronary artery atherosclerosis and it＇s hard to cure. Recently, the development of the cardiac tissue engineering offers us a new solution to cure such disease. Cardiac tissue engineering mainly contained three parts： the acquirement of the stem cell, the development of the stent material and the construction of the cardiac tissue. However, the acquirement of the stem cell is crucial. Here, we summarize the development of the stem cell research from the very beginning. There are mainly five stem cells： cardiac progenitor cells, embryo stem cells, mesenchymal stem cells, induced pluripotent stem cells, and endothelial progenitor cells.

关 键 词：心肌 组织再生 组织工程 干细胞 

分 类 号：R541[医药卫生—心血管疾病] R318.11[医药卫生—内科学]