晚孕肝炎患者凝血功能的研究和临床意义  

Study on the coagulation function in late-pregnancy women with viral hepatitis and its clinical significance

作　　者：付杰[1] 张睿[1] 解丽丽[1] 李简微[1] 董志武 

机构地区：[1]鸡西市人民医院检验科,黑龙江鸡西158100 [2]上海第六人民医院金山分院,上海201599

出　　处：《检验医学》2015年第3期247-249,共3页Laboratory Medicine

摘　　要：目的观察晚孕肝炎患者凝血指标的变化,探讨其临床意义。方法将134例晚孕病毒性肝炎患者分为急性肝炎组(39例)、慢性肝炎轻度组(43例)、慢性肝炎中重度组(25例)、肝硬化组(15例)和重症肝炎组(12例),检测凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)3项指标,并与45例正常晚孕者比较;同时观察26例正常晚孕者、23例晚孕慢性肝炎轻度患者、13例慢性肝炎中重度患者和10例肝炎肝硬化患者的凝血因子(Ⅱ、Ⅴ、Ⅶ、Ⅷ、Ⅸ、Ⅺ、Ⅻ)指标的变化。结果与正常晚孕组比较,重症肝炎组PT、APTT明显延长(P<0.05),肝炎肝硬化组和重症肝炎组FIB明显降低(P<0.05、P<0.01)。慢性肝炎轻度组和中重度组FⅦ:C低于正常晚孕组(P<0.05);除FⅧ:C外,肝硬化组凝血因子均低于正常晚孕组(P<0.05)。结论病毒性肝炎影响晚孕患者凝血功能,监测凝血指标和凝血因子变化对预防肝炎患者产后大出血及其他并发症具有重大临床意义。Objective To observe the variation of coagulation function and discuss its clinical significance in latepregnancy women with viral hepatitis.Methods A total of 134 late-pregnancy women with viral hepatitis were classified into 5 subgroups： acute hepatitis（39 cases）,chronic mild hepatitis（43 cases）,chronic moderate / severe hepatitis（25 cases）,cirrhosis（15 cases） and severe hepatitis（12 cases） groups.The prothrombin time（PT）,activated partial thromboplastin time（APTT） and fibrinogen（FIB） were determined and compared with the results of 45 normal late pregnant women.Meanwhile,the blood coagulation factors,including FⅡ,FⅤ,FⅦ,FⅧ,FⅨ,FⅪ and FⅫ,of 23 chronic mild hepatitis patients,13 chronic moderate hepatitis patients,10 cirrhosis patients and 26 normal late pregnant women,were measured respectively.Results Compared with normal late pregnancy group,PT and APTT were prolonged in severe hepatitis group（P〈0.05）.FIB decreased in both cirrhosis group and severe hepatitis group（P〈0.05,P〈0.01）.FⅦ： C in chronic mild hepatitis and chronic moderate hepatitis groups were lower than that in normal pregnant group.Most coagulation factors,except FⅧ： C,in cirrhosis group were lower than those in the normal late-pregnancy group（P〈0.05）.Conclusions Coagulation function in late-pregnancy women is affected with viral hepatitis.It is of great clinical significance to determine the coagulation indices for preventing postnatal hemorrhea and other complications.

关 键 词：凝血功能 晚孕 病毒性肝炎 

分 类 号：R446.1[医药卫生—诊断学]