非酒精性脂肪性肝病的研究进展  

Research Advances in Nonalcoholic Fatty Liver Disease

作　　者：张海峰[1] 薛明明[1] 

机构地区：[1]内蒙古医科大学基础医学院,呼和浩特010110

出　　处：《医学综述》2015年第6期1020-1022,共3页Medical Recapitulate

基　　金：内蒙古医科大学青年创新基金(YKD2013QNCX003);内蒙古医科大学博士启动资金(bsjj201401)

摘　　要：非酒精性脂肪性肝病(NAFLD)是以患者无过量饮酒史但肝实质细胞脂肪变性为病理特征的一类临床综合征,包括单纯性脂肪肝、非酒精性脂肪性肝炎和肝纤维化和肝硬化,部分患者甚至可进展为肝癌。近年来,对NAFLD的机制研究是较为活跃的领域之一,并且取得丰硕成果。该文对胰岛素抵抗、过氧化物酶体增殖物的激活和内质网应激对NAFLD的影响进展予以综述。Nonalcoholic fatty liver disease（ NAFLD） refers to a spectrum of disorders characterized by hepatic fat accumulation ranging from simple steatosis to severe nonalcoholic steatohepatitis（ NASH）,liver fibrosis and cirrhosis,and even liver cancer in some cases,and has been increasingly recognized as a major cause of liver-related morbidity and mortality. In recent years,study of NAFLD＇ s mechanisms is one of the most active fields and has made great achievements. Here is to make a review of the influence of insulin resistance,peroxisome proliferator activation and endoplasmic reticulum stress on NAFLD.

关 键 词：非酒精性脂肪性肝病 胰岛素抵抗 过氧化物酶体增殖物激活 内质网应激 

分 类 号：R333[医药卫生—人体生理学]