抗心肌缺血药物的研究进展  

Progress in Anti-ischemic Drugs Research

作　　者：蒋炜[1] 樊鹏程[1] 马慧萍[1] 景临林[1] 贾正平[1] 

机构地区：[1]兰州军区兰州总医院药剂科全军高原环境损伤防治研究重点实验室,兰州730050

出　　处：《医学综述》2015年第6期1064-1066,共3页Medical Recapitulate

基　　金：国家自然科学基金(81202458;81402848);甘肃省自然科学杰出青年基金(145RJDA331)

摘　　要：缺氧可引起组织严重损伤,常见的引起缺氧的疾病包括脑卒中、急性高山病、冠状动脉粥样硬化所导致的心肌梗死等。心肌缺血损伤是由于心肌细胞供氧不足而造成的心肌细胞坏死或功能受损;而缺血/再灌注损伤是血液中的氧与受损心肌细胞反应,形成的氧自由基对心肌细胞所造成的损伤。该文主要介绍近年来抗心肌缺血药物的研究进展及其抗心肌缺血的主要机制以及常用的缺氧和缺血药物研究模型。Hypoxia can cause severe tissue damage. Common diseases related to hypoxia include stroke,acute mountain sickness and myocardial infarction caused by coronary atherosclerosis. Myocardial ischemia damage is myocardial cell necrosis or dysfunction caused by lack of oxygen and myocardial ischemia. When ischemia-reperfusion occurs,oxygen in blood enters the damaged myocardial cells,then biochemical reactions in the damaged myocardial cells produce oxygen free radicals which could induce more serious injury to the myocardial cells. Here introduces the research advances of anti-myocardial ischemia drugs,their mechanisms and the models of hypoxia and ischemia used in the drug research in recent years.

关 键 词：缺血/再灌注 抗心肌缺血药物 缺氧模型 缺血模型 

分 类 号：R966[医药卫生—药理学]