齐多夫定三联高效抗逆转录病毒治疗对HIVAIDS感染患儿T淋巴细胞及亚群的影响  

Effect of zidovudine triple highly active antiretroviral therapy on T lymphocyte subsets in treating HIVAIDS infection children

作　　者：刘君 周容仲[2] 

机构地区：[1]湖北省枣阳市疾病预防控制中心急诊科 [2]湖北省枣阳市第一人民医院急诊科,湖北枣阳441200

出　　处：《海南医学院学报》2015年第5期673-675,678,共4页Journal of Hainan Medical University

基　　金：湖北省卫生厅计划项目(鄂卫2010-17)~~

摘　　要：目的:研究齐多夫定三联高效抗逆转录病毒治疗对HIVAIDS感染患儿T淋巴细胞及亚群的影响。方法:将在本院就诊的150例艾滋病患儿纳入研究对象,随机分为3组,高效抗逆转录病毒治疗(highly active antiretroviral therapy,HAART)组接受齐多夫定、拉米夫定、奈韦拉平三联高效抗逆转录病毒治疗,核苷类反转录酶抑制剂(NRTIs)组接受齐多夫定治疗,非核苷类反转录酶抑制剂(NNRTIs)组接受奈韦拉平治疗。治疗后6个月时,检测检测HIV抗体阳性情况、HIV-RNA阳性情况以及外周血中CD3+T细胞、CD4+T细胞、CD8+T细胞含量。结果:(1)HIV感染情况:治疗后6个月时,HAART组的HIV-RNA阳性率/HIV-RNA阳性率均低于NRTIs组和NNRTIs组(4.00%vs.18.00%vs.24.00%,6.00%vs.22.00%vs.20.00%);(2)T淋巴细胞亚群含量:3组的CD4+T细胞、CD8+T细胞的含量有差异,且HAART组的CD4+T细胞含量高于NRTIs组和NNRTIs组(37.24±5.47 vs.25.82±4.24 vs.24.69±3.95),CD8+T细胞含量低于NRTIs组和NNRTIs组(22.94±3.29vs.29.21±4.05 vs.30.46±4.59)。结论:齐多夫定三联高效抗逆转录病毒治疗有助于抑制HIV病毒,调节T淋巴细胞亚群含量,提高机体的细胞免疫功能。Objective： To study the effect of zidovudine triple highly active antiretroviral therapy on T lymphocyte sub- sets in treating HIVAIDS infection children. Methods.. A total of 150 cases of HIVAIDS infection children in our hospital from 2012 Marchto 2014 March were enrolled and divided into three groups. HAART group received zidovudine, lamivudine, nevi- rapine triple highly active antiretroviral therapy, NRTIs group received zidovudine treatment, NNRTIs group received nevirap- ine treatment. Then 6 months, 12 months, 18 months after treatment, HIV antibody positive cases, HIV-RNA positive cases and peripheral blood CD3＋ T cells, CD4＋ T cells and CD8＋ T cell content were detected. Results： 6 months after treatment, HIV-RNA positive rate and HIV-RNA positive rate of HAART group were significantly lower than those of NRTIs group and NNRTIs group（4.00% vs. 18.00% vs. 24.00%, 6.00% vs. 22.00% vs. 20.00%）. CD4＋ and CD8＋ T cell content in three groups were different; CD4＋ T cells of HAART group were significantly higher than NRTIs group and NNRTIs group （37.24 ±5.47 vs. 25.82± 4.24 vs. 24.69± 3.95）, CD8 ＋ T cell content was significantly lower than NRTIs group and NNRTIs group （22.94±3.29 vs. 29.21±4.05 vs. 30.46±4.59）. Oonciusion： Zidovudine triple highly active antiretroviral therapy is helpful to inhibit HIV virus, regulate T lymphocyte subsets and improve cellular immune function; it＇s an ideal method in trea ring HIVAIDS infection children.

关 键 词：艾滋病 齐多夫定 高效抗逆转录病毒 T淋巴细胞亚群 

分 类 号：R512.91[医药卫生—内科学]