海洋星虫多糖原料药稳定性试验研究  

Study on the Stability of Sipunculus nudus Polysaccharide

作　　者：刘玉明[1] 钱甜甜[1] 蒋定文[1] 何颖[1] 沈先荣[1] 江叔奇[2] 

机构地区：[1]海军医学研究所,上海200433 [2]浙江中医药大学,浙江杭州310053

出　　处：《现代中药研究与实践》2015年第1期69-71,共3页Research and Practice on Chinese Medicines

基　　金：国家科技重大专项新药创制项目(2008ZXJ09004-027)

摘　　要：目的研究海洋星虫多糖原料药的稳定性。方法海洋星虫多糖原料药经强光照射(4500lx)10d、高温存放(60℃)10 d、高湿存放[25℃,RH(75±5)%]10 d、加速试验[(40±2)℃,RH(75±5)%]6个月、长期试验1年,考察海洋星虫多糖原料药经不同条件存放后的性状、干燥失重、微生物限度及多糖含量的变化。结果海洋星虫多糖原料药除高湿试验外,其它试验所考察指标均符合质量标准要求。结论海洋星虫多糖原料药稳定性较好,但具有吸湿性。Objective To investigate the stability of Sipunculus nudus polysaccharide crude materials.Methods The raw material of Sipunculus nudus polysaccharide was treated respectively with high light（4500lx,10d）for 10 days,high temperature（60℃）for 10 days,high wet（25℃,RH75%±5%）for 10 days,accelerating testing（40℃±2℃,RH75%±5%）for six months,and a long-term testing（25℃±2℃,RH60%±10%）of one year,and then the changes of characters,drying shrinkage,microbial limit and the contents of polysaccharide under different storage conditions were observed.Results All of the tested indexes of the sample were consistent with the quality standards after the series tests except the high wet test. Conclusion The tested material is stable but is hygroscopicity.

关 键 词：海洋星虫多糖 稳定性 影响因素试验 加速试验 长期试验 

分 类 号：R927.1[医药卫生—药学]