代谢综合征对中青年高血压患者颈动脉内膜中层厚度的影响  

Influence of metabolic syndrome on carotid intima-media thickness in young and middle-aged patients with essential hypertension

作　　者：汤峥丽[1] 张晓一[1] 张晓天[1] 

机构地区：[1]上海中医药大学附属曙光医院,上海201203

出　　处：《上海预防医学》2015年第3期113-115,共3页Shanghai Journal of Preventive Medicine

摘　　要：[目的]探讨代谢综合征(MS)对中青年原发性高血压(EH)患者颈动脉内膜中层厚度(IMT)的影响。[方法]将168例中青年EH患者按是否合并MS分为MS组(88例)和非MS组(80例),采用超声检测仪测定颈动脉IMT,同时测定体质指数(BMI)、腰围(WC)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等相关数据进行比较。[结果]MS组的BMI、WC、FPG、TC、TG、LDL-C、IMT均明显高于非MS组,而HDL-C明显低于非MS组(P值均<0.05)。多因素Logistic回归分析显示,年龄、SBP、FPG、LDL-C为颈动脉IMT增厚的相关因素。[结论]MS对中青年EH患者的IMT有显著影响,其与高血压共同参与动脉粥样硬化过程,在治疗中除降低血压外,还要及早纠正代谢紊乱,预防动脉硬化引起并发症。Objective] To evaluate the influence of metabolic syndrome （ MS） on carotid intima-media thickness （ IMT） in essential hypertension （ EH） . [ Methods] A total of 168 young and middle-aged EH patients were divided into MS group （88 cases） and non-MS group （80 cases）.Between the two groups were measured and compared IMT , body mass index （ BMI ） , waist circumference （ WC ） , systolic blood pressure （ SBP ） , diastolic blood pressure （ DBP ） , fasting plasma glucose （ FPG ） , total cholesterol （TC）,triglyceride （TG）,high-density lipoprotein （HDL-C）,low-density lipoprotein （LDL-C） and others. [ Results] Comparison between MS group and non-MS group showed that the level of BMI , FPG, WC, TC, TG, LDL-C and IMT were higher in MS group,P all ＆lt;0.05.Multiple Logistic regression analysis showed that age,SBP,FPG and LDL-C were the related factors for carotid IMT. [Conclusion] MS is associated with carotid IMT in young and middle-aged patients with EH .MS and EH may jointly participate in the process of atherosclerosis .Apart from control of blood pressure , correction of metabolic disorders is also necessary in order to prevent complication of atherosclerosis .

关 键 词：代谢综合征 原发性高血压 颈动脉内膜中层厚度 

分 类 号：R544.1[医药卫生—心血管疾病]