有机质谱联用技术测定砷制剂及其降解产物的研究进展  

Recent Advances in Application of HPLC-MS/MS Coupling Technique in Arsenic Compounds and Its Degradation Products Analysis

作　　者：计峰[1] 常碧影[2] 苏琪[3] 黄建国[1] 王雅蕾[1] 马春建[1] 

机构地区：[1]北京市农林科学院畜牧兽医研究所,北京100097 [2]中国农业科学院农业质量标准与检测技术研究所,北京100081 [3]中国农业科学院北京畜牧兽医研究所,北京100193

出　　处：《中国畜牧杂志》2015年第7期91-96,共6页Chinese Journal of Animal Science

基　　金：北京市农林科学院创新基金(CXJJ201317);北京市优秀人才培养资助计划(2013D002020000001)

摘　　要：用作饲料添加剂的有机砷类制剂主要指洛克沙胂和阿散酸,饲喂给动物后多随粪便排出,进入环境可降解、转化为水溶性更强、毒性更大的无机砷,进而威胁人类的安全。近年来,国内外围绕着是否在饲料中使用有机砷添加剂争论不休,关键是由于人们对其在环境中的降解、转化和迁移规律缺乏认识。本文综述了液相色谱-质谱联用技术测定有机砷形态的研究进展,并根据多级有机质谱联用技术鉴定化合物分子结构的优势,分析了它在解析有机砷的降解产物及其转化规律研究中的应用前景。As feed additives, organoarsenic compounds （roxarsone and arsanilic acid） were mainly excreted with feces after being fed to animals. It can be degraded and transformed into some kinds of water-soluble inorganic arsenic with much stronger toxicity in environment, thus threating the safety of human. During recent years, whether to use arsenic feed additives is in debate. The knowledge of degradation and transformation patterns of organoarsenic additives in environment is still lacking. A review of the application of the coupling techniques of high-performance liquid chromatography （HPLC） with mass spectrometry （HPLC-MS/MS） to the analysis of organic arsenic speciation was presented. With the advantage in identifying the molecular structure of unknown compounds according to the multi- level MS technology, the application of HPLC-MS/MS to the analysis of organoarsenic compounds and its degradation products will be more and more wide.

关 键 词：有机砷 联用技术 降解 高效液相色谱-电喷雾质谱联用仪 串联质谱法 

分 类 号：S816.17[农业科学—饲料科学]