直压辅料结晶山梨醇的粉体学性能评价  

Study on powder technology of D-sorbitol in direct compression

作　　者：陈华[1,2] 王暖升 尹宗美 纪伟 

机构地区：[1]青岛科技大学,山东青岛266000 [2]青岛明月海藻集团有限公司,山东青岛266400

出　　处：《精细与专用化学品》2014年第10期36-38,共3页Fine and Specialty Chemicals

摘　　要：结晶山梨醇由山梨醇粉末和熔融山梨醇混合结晶制备,产品经过粉碎后,通过不同目数的筛网,得到粒度大小不同的三种粉末。对不同粒度的结晶山梨醇做粉体综合特征测试,通过休止角、压缩度描述其流动性,为粉末直接压片工艺提供工艺参数。综合各项粉体性质,样品B做直接压片效果最佳。山梨醇用于直接压片工艺要控制产品的粒度,200目以下细粉的含量控制在10%左右。Crystalline D-sorbitol is preprated by mixed-crystallization of sorbitol power with melt sorbitol, after crushing three different size granules are obtained by changing sieve in different standard. To approach the parame- ters for direct compression, D-sorbitol flowability was characterized by the angle of repose and direct compressibili ty. In consideration of micromeritics characteristics, the compactibilty of B was the best. Results shown as appropriate size of D-sorbitol can meet the requirement of the process of direct compression technology if finer powder＇s content under 200 mesh should be controlled in 10 percent.

关 键 词：直接压片 流动性 粉体学 

分 类 号：R944[医药卫生—药剂学]