基于双弹性腔模型与整心动周期脉搏波的血流动力学参数估计  

Estimation of Hemodynamic Parameters Based on Double-windkessel Model and the Contour of Whole Period of Pulse Wave

作　　者：徐礼胜[1,2] 刘佳[1] 何殿宁[1] 王昊[1] 关德君[3] 

机构地区：[1]东北大学中荷生物医学与信息工程学院,沈阳110819 [2]东北大学教育部医学影像计算重点实验室,沈阳110819 [3]沈阳广播电视大学信息工程学院,沈阳110003

出　　处：《北京工业大学学报》2014年第10期1570-1578,共9页Journal of Beijing University of Technology

基　　金：教育部博士点基金资助项目(20110042120037);国家自然科学基金资助项目(61374015)

摘　　要：为了对心脏疾病的诊断和治疗提供指导,同时也为进行心脏辅助装置的设计及评价提供有利的工具,提出了基于双弹性腔模型和整心动周期脉搏波的血流动力学参数估计方法,运用非线性最小二乘Levenberg-Marqurdt算法对实测脉搏波数据进行参数估计得到动脉系统的模型参数,即人体的血流动力学参数(包括外周阻力、动脉顺应性和血流惯性).利用MATLAB/Simulink工具结合图形用户界面(graphical user interface,GUI)建立的左心与动脉系统耦合的动力学电路模型得到的仿真结果与人体实测脉搏波数据进行对比分析,验证了模型参数估计的有效性.用该方法估计的参数结果符合生理参数范围,且效果优于传统的舒张期估计方法,其中主动脉顺应性参数的估计结果误差降低了50%,参数带入模型得到的仿真结果与实测脉搏波之间的误差也降低了20%左右.To provide guidance to the diagnosis and treatment of heart disease, provide a useful tool for design and evaluation of heart assist devices for people, in this paper, the hemodynamic parameters estimation method of the entire heartbeat cycle of the pulse wave based on Double-Windkessel model is proposed, using Levenberg-Marqurdt algorithm to estimate the model parameters of arterial system based on measured pulse wave. Dynamics circuit model of left heart arterial coupling system is built by MATLAB/Simulink tools combining with the graphical user interface （GUI）. The validity of the estimation is verified by analyzing and comparing the simulation result with the measured pulse wave data. Results of the estimated parameters are in agreement with the range of physiological parameters, and the effect is superior to the traditional diastolic phase estimation method, the error of estimated result of aortic compliance is reduced 50%, and putting parameters into the model, the error between the simulation results with the measured pulse wave is significantly reduced about 20% than that estimated bytraditional diastolic phase estimation method.

关 键 词：参数估计 双弹性腔 左心-动脉系统 脉搏波 血流动力学 

分 类 号：R318[医药卫生—生物医学工程]