Synthesis, Crystal Structure and Property of a Binuclear Copper Complex [Cu_2L_2(pht)_2]_2·H_2O  

作　　者：胡喜兰 施鹏飞 姜琴 许瑞波 尹福军 王大奇 

机构地区：[1]School of Chemical Engineering, Huaihai Institute of Technology [2]Jiangsu Key Laboratory of Marine Biotechnology [3]College of Chemistry and Chemical Engineering,Liaocheng University

出　　处：《Chinese Journal of Structural Chemistry》2014年第9期1281-1286,共6页结构化学（英文）

基　　金：supported by the National Natural Science Foundation of China(No.21101069);Natural Science Foundation of the Higher Education Institutions of Jiangsu Province(13KJB150005);the Open Foundation of Jiangsu Key Laboratory of Marine Biotechnology(No.HS12006);the Priority Academic Program Development of Jiangsu Higher Education Institutions

摘　　要：A new binuclear copper complex, [Cu2L2（pht）2]2·H2O （Hpht = 5,5-diphenylhy- dantoin, i.e. phenytoin; L = 2-diethylaminoethanol）, has been synthesized by the solvothermal method, and characterized by elemental analysis, IR and single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group C2/c with a = 31.918（3）, b = 12.9222（15）, c = 19.868（2） A,β = 98.762（2）°, V= 8098.8（16） A3, Dc = 1.429 Mg/m3, Z= 4, F（000） = 3640, p = 1.107 mm-1, R = 0.0560 and wR = 0.1276 （1 〉 20（/））. Each copper（Ⅱ） in a molecule is coordinated with N and O atoms from ligand L and N atom from ligand Hpht in a tetradentate manner. Moreover, two copper（Ⅱ） centers are bridged by two O atoms of hydroxyl groups from two L ligands to form a slightly distorted binuclear {Cu202} diamond configuration. In addition, the interaction of this complex with calf thymus DNA （CT-DNA） was investigated by UV-vis spectrum and viscometry, and the complex may bind to DNA through intercalation.A new binuclear copper complex, [Cu2L2（pht）2]2·H2O （Hpht = 5,5-diphenylhy- dantoin, i.e. phenytoin; L = 2-diethylaminoethanol）, has been synthesized by the solvothermal method, and characterized by elemental analysis, IR and single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group C2/c with a = 31.918（3）, b = 12.9222（15）, c = 19.868（2） A,β = 98.762（2）°, V= 8098.8（16） A3, Dc = 1.429 Mg/m3, Z= 4, F（000） = 3640, p = 1.107 mm-1, R = 0.0560 and wR = 0.1276 （1 〉 20（/））. Each copper（Ⅱ） in a molecule is coordinated with N and O atoms from ligand L and N atom from ligand Hpht in a tetradentate manner. Moreover, two copper（Ⅱ） centers are bridged by two O atoms of hydroxyl groups from two L ligands to form a slightly distorted binuclear {Cu202} diamond configuration. In addition, the interaction of this complex with calf thymus DNA （CT-DNA） was investigated by UV-vis spectrum and viscometry, and the complex may bind to DNA through intercalation.

关 键 词：copper（Ⅱ） complex SYNTHESIS crystal structure DNA binding 

分 类 号：O627.12[理学—有机化学]