Synthesis, Crystal Structure, and Thermal Stability of a Dibutyltin Complex {[4-Et_2NC_6H_3(O)C=NC_6H_3(O)-5-NO_2](n-Bu_2Sn)}_2 and Its Interaction with DNA  

作　　者：张志坚 邝代治 蒋伍玖 庾江喜 朱小明 张复兴 

机构地区：[1]Department of Life Science, Hengyang Normal University [2]Department of Chemistry and Material Science, Key Laboratory of Functional Organometallic Materials of Hunan Provincial College,Hengyang Normal University

出　　处：《Chinese Journal of Structural Chemistry》2014年第9期1319-1325,共7页结构化学（英文）

基　　金：supported by the Natural Science Foundation of Hunan Province (No. 13JJ3112);Scientific & Technological Projects of Hunan Province (No. 2013TZ2025, 2014FJ3060);Scientific Research Fund of Hunan Provincial Education Department of China (14C0171);the Foundation of Key Laboratory of Functional Organometallic Materials,University of Hunan Province(No. 13K03, 13K04, 13K05);the Science Foundation of Hengyang Normal University (No. 12C45, 13A21)

摘　　要：The Schiff base organotin（IV） complex {[4-Et2NC6H3（O）C=NC6H3（O）-5-NO2]（n- Bu2Sn）}2 has been synthesized via the reaction between 4-（diethylamino） salicylaldehyde-2-arnino- 4-nitrophenol Schiff base （H2L） and dibutyltin oxide. Complex C1 has been characterized by IR, 1H NMR, 13C NMR spectra, and elemental analysis, and its crystal structure was determined by X-ray diffraction, It crystallizes in the monoclinic system, space group P21/n with a = 15.6559（8）, b = 9.1657（5）, c = 18.8351（10） ]A, β = 107.3440（10）°, Z = 4, V = 2579.9（2） A3, Dc = 1.442 Mg.m-3, μ（MoKa） = 1.025 mm-1, F（000） = 1152, R = 0.0250 and wR = 0.0633. The central Sn atom is coordinated in a hexadentate manner to assume a distorted octahedral configuration. Complex C1 was studied by TGA analysis in air atmosphere. The interaction between complex C1 and the herring sperm DNA was realized through the intercalation of the complex based on the studies by EB fluorescent probe.The Schiff base organotin（IV） complex {[4-Et2NC6H3（O）C=NC6H3（O）-5-NO2]（n- Bu2Sn）}2 has been synthesized via the reaction between 4-（diethylamino） salicylaldehyde-2-arnino- 4-nitrophenol Schiff base （H2L） and dibutyltin oxide. Complex C1 has been characterized by IR, 1H NMR, 13C NMR spectra, and elemental analysis, and its crystal structure was determined by X-ray diffraction, It crystallizes in the monoclinic system, space group P21/n with a = 15.6559（8）, b = 9.1657（5）, c = 18.8351（10） ]A, β = 107.3440（10）°, Z = 4, V = 2579.9（2） A3, Dc = 1.442 Mg.m-3, μ（MoKa） = 1.025 mm-1, F（000） = 1152, R = 0.0250 and wR = 0.0633. The central Sn atom is coordinated in a hexadentate manner to assume a distorted octahedral configuration. Complex C1 was studied by TGA analysis in air atmosphere. The interaction between complex C1 and the herring sperm DNA was realized through the intercalation of the complex based on the studies by EB fluorescent probe.

关 键 词：organotin complex SYNTHESIS crystal structure thermal stability DNA 

分 类 号：O641.4[理学—物理化学]