Cochrane Overview的研究现状及制作方法调查  

Research Status and Development Methods of Cochrane Overviews:A Survey

作　　者：高洪阳 赵阳[1] 高蕊[1] 李博[1] 

机构地区：[1]中国中医科学院西苑医院临床药理研究所,北京100091

出　　处：《中国循证医学杂志》2014年第12期1514-1519,共6页Chinese Journal of Evidence-based Medicine

基　　金：国家"重大新药创制"创新药物研究开发技术平台建设(编号:2012ZX09303-010-002);国家自然科学基金青年项目(编号:81303151)

摘　　要：目的了解Cochrane Overview的研究现状及制作方法。方法计算机检索h e Cochrane Library和Pub Med数据库,搜集Cochrane Overview,检索时限均截至2014年3月。由两位研究者按照纳入与排除标准筛选文献、提取资料,并对纳入Cochrane Overview的检索策略、质量评价、统计方法、研究结果进行评价和分析。结果共纳入18个Cochrane Overview,其中有4个(22.2%)进行了正式的间接比较,8个(44.4%)仅进行了直接比较,6个(33.4%)仅对现有研究进行汇总分析,但未合并数据;12个(66.7%)将检索限定在h e Cochrane Library中,6个(33.3%)检索了其他数据库;14个(77.8%)采用AMSTAR量表进行文献质量评价,12个(66.7%)采用GRADE系统进行证据质量评价;9个(50%)产生了新的研究结果。结论目前Cochrane Overview的制作与报告规范尚不成熟,研究者应根据不同的研究目的选用适宜的制作方法。Objective To investigate the status of research and development methods of Cochrane overviews. Methods the Cochrane Library and Pub Med were searched up to March 2014 to identify Cochrane overviews. According to the inclusion and exclusion criteria,two reviewers independently screened literature,extracted data,and assessed and analyzed search strategy,quality assessment method,data analysis,and study results. Results A total of 18 Cochrane overviews were included. Among them,4（22.2%） overviews included formal statistical indirect comparison; 8（44.4%） included only results from direct comparison; 6（33.4%） only systematically analyzed current studies without data pooling; 12（66.7%） only searched h e Cochrane Library,while 6（33.3%） expanded search to other databases; 14（77.8%） applied the AMSTAR tool to assess methodological quality of included literature; 12（66.7%） applied the GRADE system to assess the quality of evidence; and 9（50%） yielded new outcomes. Conclusion Currently,the development and reporting standards of Cochrane overviews are still immature. Investigators should choose proper methods based on research objectives when developing Cochrane overviews.

关 键 词：系统评价再评价 系统评价 间接比较 网状Meta分析 AMSTAR GRADE 

分 类 号：R195[医药卫生—卫生统计学]