微波辐射下一锅法合成5-氰基-6-芳基硫脲嘧啶  

Microwave-Assisted One-Pot Synthesis of 5-cyano-6-aryl-2-thiouracils

作　　者：崔朋雷[1] 李晓慧[1] 张冬暖[1] 刘卉敏[1] 张英群[1] 

机构地区：[1]河北农业大学理学院,河北保定071001

出　　处：《西南大学学报（自然科学版）》2014年第7期79-83,共5页Journal of Southwest University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(21372060);保定市科技计划支撑项目(12ZF077);河北农业大学社科和理工基金资助项目(LG201204)

摘　　要：在微波辐射下,以哌啶为催化剂,由芳香醛、氰基乙酸乙酯与硫脲一锅法反应合成了一系列5-氰基-6-芳基硫脲嘧啶类化合物,产物结构经核磁共振、质谱等方法确证.该反应时间短,操作简便,收率较高,为合成5-氰基-6-芳基硫脲嘧啶类化合物提供了一种简便有效的方法.A series of 5-cyano-6-aryl-2-thiouracils were synthesized via one-pot reactions of aromatic alde hydes, ethyl cyanoacetate and thiourea catalyzed by piperidine under microwave irradiation. The product were confirmed by NMR, mass spectrometry method. This method have several advantages such as high yields, easy work-up and short reaction time, which provide a simple and effective method for the synthe- sis of 5 cyano-6-aryl-2-thiouracils.

关 键 词：微波辐射 5-氰基-6-芳基硫脲嘧啶 一锅法 哌啶 

分 类 号：O621.25[理学—有机化学]