西尼罗病毒感染免疫应答反应研究进展  

Research advances in immune response to West Nile virus infection

作　　者：王化磊[1] 金宏丽 郑学星[1] 杨松涛[1] 夏咸柱[1] 

机构地区：[1]解放军军事医学科学院军事兽医研究所病毒学研究室吉林省人兽共患病预防与控制重点实验室,长春130122 [2]长春西诺生物科技有限公司,130012

出　　处：《传染病信息》2015年第1期59-64,共6页Infectious Disease Information

基　　金：国家科技支撑计划项目(2013BAD12B04)

摘　　要：西尼罗病毒病是由西尼罗病毒引起的一种人兽共患传染病,给人类和动物健康带来重大危害。虽现已有疫苗处在研究阶段,但仍没有人用疫苗获批上市。通过感染动物模型,有关西尼罗病毒免疫反应的研究已经开展。本文对固有免疫和获得性免疫在抵抗西尼罗病毒感染中的作用进行综述,为进一步研究西尼罗病毒激发免疫应答反应的机制和新型疫苗研制提供依据。The West Nile virus（WNV） disease is a zoonosis caused by WNV, which poses great threat to the health of human and animals. Although there have been several candidates in clinical trials, there are no approved vaccines of WNV disease in human. From studies of infected animal models, a great deal has been learned concerning the immune response to infection with WNV. The authors provide an overview of the mechanisms by which the innate and adaptive immune response can limit dissemination of WNV infection, in hope of providing strategies for future mechanism study of motivating immune response and development of novel vaccines against WNV.

关 键 词：西尼罗病毒 西尼罗热 免疫系统 

分 类 号：R373.31[医药卫生—病原生物学]