功能磁共振成像观察复发缓解型多发性硬化患者运动相关脑区的局部一致性  

Functional magnetic resonance imaging observation on regional homogeneity ofmotor-related cortex in patients with relapsing-remitting multiple sclerosis

作　　者：熊华[1] 李咏梅[1] 曾春[1] 王静杰[1] 刘义[1] 杜思霖[1] 孟奔[2] 

机构地区：[1]重庆医科大学附属第一医院放射科,重庆400016 [2]重庆市肿瘤医院医学影像科,重庆400016

出　　处：《中国医学影像技术》2015年第3期327-330,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(81371523);国家临床重点专科建设项目([2013]544);重庆市卫生局资助项目(2011-1-031;2012-1-017)

摘　　要：目的采用静息态功能磁共振(rs-fMRI)区域局部一致性(ReHo)技术,观察复发缓解型多发性硬化(RRMS)患者脑局部ReHo值。方法收集19例RRMS患者(RRMS组)与19名年龄、性别相匹配的健康对照者(对照组)行rsfMR和常规MR检查。分别提取两组左、右侧运动相关脑区ReHo值行两样本t检验分析,对RRMS组双侧运动相关脑区ReHo值与患者EDSS评分行相关性分析。结果与正常对照组相比,RRMS患者双侧运动相关脑区ReHo值降低(P<0.05,经AlphaSim校正,体素>20),患者双侧运动相关脑区ReHo值与EDSS评分均呈负相关(右侧:r=-0.819,P<0.05;左侧:r=-0.871,P<0.05)。结论 RRMS患者运动相关脑区神经元活动一致性存在减低改变,这种改变可能是患者运动功障碍形成的相关因素之一。Objective To observe the regional homogeneity（ReHo）value of motor-related cortex in patients with relapsing-remitting multiple sclerosis（RRMS）using resting state functional magnetic resonance imaging（rs-fMRI）.MethodsNineteen patients with RRMS（RRMS group）and 19gender-and age-matched healthy controls（control group）underwent rs-fMRI and conventional MRI.Bilateral motor-related cortex were selected as ROIs to measure ReHo values and were analyzed by two sample t test,Correlation analysis was performed between the ReHo values and expended disability status scale（EDSS）.Results Compared with control group,the ReHo values of motor-related cortex in RRMS group decreased（P〈0.05,AlphaSimcorrection,voxel〉20）.The bilateral ReHo values showed negative correlation with EDSS（right r=-0.819,P〈0.05,left r=-0.871,P〈0.05）.Conclusion ReHo values of motor-related cortex in RRMS patients have been decreased,which may be one of the relevant factors related to disability.

关 键 词：多发性硬化 局部一致性 功能磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R744.51[医药卫生—诊断学]