原儿茶醛对大鼠慢性非细菌性前列腺炎的治疗作用  

The treatment of protocatechuic aldehyde on chronic nonbacterial prostatitis in rats

作　　者：纪必磊 刘小丽[1] 张晶[1] 

机构地区：[1]深圳市第三人民医院急诊科,广东深圳518114

出　　处：《中国医药科学》2015年第3期26-28,31,共4页China Medicine And Pharmacy

摘　　要：目的观察原儿茶醛对大鼠慢性非细菌性前列腺炎的治疗作用并探讨其作用机制。方法 SPF级雄性大鼠50只,随机分为假手术组、模型组、前列康组,原儿茶醛低剂量组和高剂量组,每组10只。连续30d皮下注射苯甲酸雌二醇造模,之后分别灌胃对应药4周,假手术组、模型组给予等量生理盐水,实验结束后,检测前列腺湿重,前列腺组织匀浆白细胞总数、卵磷脂小体密度、TNF-α、IL-8含量及前列腺组织病理学观察。结果与模型组比较,原儿茶醛低剂量组明显降低白细胞数,升高卵磷脂小体密度(P<0.01)。原儿茶醛高剂量组明显降低前列腺湿重、白细胞数和TNF-α、IL-8含量,升高卵磷脂小体密度(P<0.01),原儿茶醛高低剂量组都能减轻前列腺间质水肿和炎症细胞浸润。结论原儿茶醛对大鼠慢性非细菌性前列腺炎具有治疗作用,且呈剂量依赖性。Objective To observe the effect of protocatechuic aldehyde on chronic nonbacterial prostatitis and to explore the mechanism of it. Methods Fifty SPF rats were randomly divided into five groups. including Sham-operated group （10）,model group （10）,qian lie kang group （10）,low-dose protocatechuic aldehyde group（10） and high-dose group （10）.Building the model with estradiol benzoate.Followed with drug given by lavage administration for 4 weeks.Sham-operated and model group gave the same dose of sodium chloride.After the experiment,detected wet weight of prostate,total number of white blood cells,the density of lecithin body,the content of TNF-αand IL-8 in prostatic tissue homogenate and observed the pathology of prostate tissue. Results Compared with the model group,total number of white blood cells decrease and the density of lecithin body increase in low-dose protocatechuic aldehyde group（P〈0.01）. The wet weight of prostate, total number of white blood cells, the content of TNF-α and IL-8 in high-dose protocatechuic aldehyde group decrease, the density of lecithin body increase（P 〈 0.01）.Both decrease infiltration of inflammatory cells and interstitial edema in prostate. Conclusion Protocatechuic aldehyde has therapeutic functions on chronic nonbacterial prostatitis in rats,appeared dose-dependent.

关 键 词：原儿茶醛 慢性非细菌性前列腺炎 大鼠 治疗作用 

分 类 号：R258.5[医药卫生—中医内科学]