人造纳米颗粒呼吸系统毒性及生物效应的研究进展  

Research advances on the toxic effects of manufactured nanoparticles on the respiratory system

作　　者：吴添舒[1] 唐萌[1] 

机构地区：[1]环境医学工程教育部重点实验室、东南大学公共卫生学院&苏州纳米科技协同创新中心、江苏省生物材料与器件重点实验室,南京210009

出　　处：《科学通报》2015年第8期729-740,共12页Chinese Science Bulletin

基　　金：国家自然科学基金(30972504,81172697,81302461,81473003);国家重大科学研究计划(2011CB933404);江苏省基础研究计划(BK2011606)资助

摘　　要：随着纳米技术在全球的迅猛发展,人造纳米颗粒已经广泛应用于生物医学领域,其生物安全性成为研究者的关注热点.由于呼吸道是人造纳米颗粒进入机体的主要途径之一,纳米颗粒对机体呼吸系统的毒性和生物效应的相关研究越来越多.本文介绍了人造纳米颗粒和纳米药物在治疗呼吸系统疾病中的应用,重点归纳了几种常见人造纳米颗粒对机体呼吸系统的毒性效应和可能的毒性作用机制,阐述了影响纳米颗粒毒性的几点因素,为今后人造纳米颗粒的研究和应用提供有价值的参考.With the rapid development of nanotechnology in recent years, manufactured nanoparticles have been increasingly used in a wide range of applications in the bio-medicine field. Meanwhile, the bio-safety of manufactured nanoparticles have received more and more attention. As inhalation is one of the primary routes where manufactured nanoparticles can enter the body, a number of studies have investigated the toxic effects of nanoparticles on the respiratory system. This review briefly introduced the application of nano-drugs for the treatment of diseases associated with the respiratory system, and then focused on the toxic effects and potential toxicity mechanisms of several common manufactured nanoparticles on the body＇s respiratory system. Further considerations of the factors influencing the toxicity of nanoparticles have also been provided. This review intended to provide valuable clues for further research into manufactured nanoparticles and their applications.

关 键 词：人造纳米颗粒 毒理学 生物效应 吸入毒性 

分 类 号：TB383.1[一般工业技术—材料科学与工程]