金纳米棒:性能、制备、修饰、生物成像技术及应用  

Properties, preparation, modification and biological imaging of gold nanorods and its applications

作　　者：杨玉东[1] 刘公召[1] 李冬至[1] 徐菁华[1] 杨林梅[1] 

机构地区：[1]沈阳工业大学理学院,沈阳110870

出　　处：《科学通报》2015年第9期817-829,1-4,共13页Chinese Science Bulletin

基　　金：国家自然科学基金(50375102);沈阳工业大学博士后启动基金资助

摘　　要：随着生物医学的发展,对生物成像技术和成像分辨率的要求越来越高,纳米材料和技术被越来越多地应用到生物医学领域.各向异性的金纳米棒由于具有较高的电子密度、较大的吸收截面、特殊的表面等离子共振光学特性、优良的生物相容性和化学稳定性而被广泛应用于生物成像领域.本文结合本课题组在该领域的研究经验,综述了金纳米棒的制备方法、光学性能和表面修饰方法;并从金纳米棒局部等离子共振特性出发,综述了金纳米棒的暗场散射成像、双光子荧光成像、光声断层成像、光学相干断层扫描、X射线计算机断层扫描、表面增强拉曼散射成像等生物成像技术.同时阐述了金纳米棒在生物成像、医学诊断和联合治疗等领域中的应用进展.Nanometer materials and nanotechnology have potential applications in the field of biomedicine, particularly in biological technology and imaging. Anisotropic gold nanorods have been widely used in the field of biological imaging as they exhibit high electron density, large absorption cross-sections, surface plasma resonances and excellent bio-compatibility, and are chemically stable. Due to the absorption of the plasmon-enhanced two-photon, gold nanorods can make scattering contrast for dark field microscopy come ture, or emit a strong two-photon. Because the unique size and shape could be exhibited depending on plasmon resonances scattering and absorption, the application of gold nanorod in biomedical imaging has been mounting rapidly. Gold nanorods also can be used in the biomedical field, such as optical coherence tomography and photoacoustic tomography. In this review, we summarize the anisotropic optical properties, preparation, surface modification of the gold nanorods. The dark field scattering imaging, two-photon fluorescence imaging, photoacoustic tomography imaging, optical coherence tomography, X-ray computed tomography and surface enhanced Raman scattering were used to investigate the properties of localized plasmon resonances of gold nanorods. We also highlight the recent progress in the application of gold nanorods in biological imaging, medical diagnosis and therapeutic alliance.

关 键 词：金纳米棒 表面等离子共振 表面修饰 生物成像 

分 类 号：TB383.1[一般工业技术—材料科学与工程]