硬枝树花中抑制H_22荷瘤小鼠肿瘤的活性成分研究  

Anti-tumor activity of the active compounds extracted from Ramalina conduplicans in H_(22) tumor-bearing mice

作　　者：唐燕霞[1,2] 包海鹰[1,2] 王新斌[1,2] 黄威[1,2] 

机构地区：[1]吉林农业大学中药材学院,吉林长春130118 [2]吉林农业大学食药用菌教育部工程研究中心,吉林长春130118

出　　处：《菌物学报》2015年第2期278-286,共9页Mycosystema

基　　金：长江学者和创新团队发展计划(IRT1134)

摘　　要：研究了从硬枝树花中提取得到的4个单体化合物松萝酸(usnic acid)、去甲环萝酸(evernic acid)、巴尔巴地衣酸(barbatic acid)和水杨嗪酸(salazinic acid)对H22荷瘤小鼠的抑瘤作用,并且对抑瘤率、胸腺指数、脾指数及小鼠白介素-2含量等各个指标的进行检测,以说明此4种化合物对小鼠肿瘤生长的抑制效果。结果表明,松萝酸高、中剂量组,去甲环萝酸高、中剂量组,巴尔巴地衣酸低剂量组,水杨嗪酸高剂量组对小鼠肿瘤有较好的抑制效果,与阴性对照组比较有极显著差异(P<0.01),并且这些组的H22荷瘤小鼠血清中白介素-2的含量显著增加,与抑制肿瘤活性具有相关性。The anti-tumor activities of usnic acid, evernic acid, barbatic acid and salazinic acid extracted from thallus of Ramalina conduplicans were studied. The anti-tumor rate, and thymus and spleen indexes were calculated and the content of serum IL-2 were detected. The results showed that usnic acid [20mg/（kg.d）, 10mg/（kg.d）], evernic acid [20mg/（kg.d）, 10mg/（kg.d）], barbatic acid [5mg/（kg.d）], and salazinic acid [20mg/（kg.d）] had obviously inhibitory effect on the tumor in H22 mice. The anti-tumor rate of these compounds were obviously higher than that of negative control （P〈0.01）. These four compounds can influence thymus and spleen indexes and the content of serum IL-2 in treated H22 mice was significantly higher than that in negative and control （P〈0.01）.

关 键 词：松萝酸 去甲环萝酸 巴尔巴地衣酸 水杨嗪酸 白介素‐2 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]