温敏性胶原基复合水凝胶的制备与表征  

Preparation and Characterization of Temperaturesensitive Collagen Based Composite Hydrogel

作　　者：胡杨[1,2] 崔国廉[1,2] 林海[1,2] 但卫华[1,2] 刘兰[1,2] 但年华[1,2] 

机构地区：[1]四川大学皮革化学与工程教育部重点实验室,四川成都610065 [2]四川大学制革清洁技术国家工程实验室,四川成都610065

出　　处：《中国皮革》2015年第5期33-36,共4页China Leather

基　　金：国家自然科学基金项目(No:21276164);国家科技支撑计划项目(No:2011BAC06B11)

摘　　要：以合成的P(NIPAM-co-AAc)共聚物为温敏成分,制备PVA-P(NIPAM-co-AAc)-Col胶原基复合水凝胶。通过响应曲面设计分别对水凝胶的抗张强度、断裂伸长率、杨氏模量、在蒸馏水和生理盐水中的溶胀率、干态透水汽性、35℃和39℃的湿态透水汽性进行了研究。同时,进行不同制备参数的验证试验,以期建立一种以数学拟合方程对各响应值进行预测的方法结果表明:采用响应曲面设计获得的回归拟合方程,在预测水凝胶性质时具有一定的准确性和可靠性,以P(NIPAM-co-AAc)共聚物作为温敏控件,能够获得具有温敏性的水凝胶。The PVA - P （ NIPAM - co - AAc） - Col hydrogel was prepared with P （ NIPAM - co - AAc ） copolymer as tempera- ture - sensitive material. The tensile strength, elongation at break, Young＇ s modulus, the swelling ratio in distilled water and sa- line,the water vapor transmission rates（WVTR） in dry condition and in wet condition at 35℃ and 39℃ of hydrogel were deter- mined via the Response Surface Methodology（RSM） .Meanwhile, the examination concerned was conducted in order to establish a method to predict response based on mathematical fitting equation. The results show that the fitting equations gained from RSM can predict the properties of the hy - sensitive. The WVTR in wet drogel in some extent. The hydrogels synthesized by P （ NIPAM - co - AAc） copolymer is temperature condition can response with the change of temperature

关 键 词：温敏性 胶原基复合水凝胶 响应曲面设计 数学方程拟合 性能预测 

分 类 号：TQ427.26[化学工程]