尿生物标记物预测原发性肾小球肾炎疗效及预后的意义  

Prediction value of urine biomarkers on treatment efficiency and prognosis of patients with primary glomerulonephritis

作　　者：翁沁婕 谢静远[1] 陈楠[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院肾脏科,上海200025

出　　处：《肾脏病与透析肾移植杂志》2015年第1期65-69,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家重点基础研究发展计划(973计划)(2012CB517604);中华医学会临床医学科研专项基金(13030280413);国家自然科学基金(81370015;81000295)

摘　　要：原发性肾小球肾炎是一组以肾小球损害为主的疾病,其病因复杂,激素和免疫抑制剂为其主要治疗方法,但药物不良反应较大,如何合理使用是肾科医师日常工作中的难题。近年来,越来越多的研究显示尿生物标记物的水平及变化在预测疾病疗效、预后等方面有重要意义,可帮助临床医师选择有效且安全的治疗方案,亦为临床工作提供了许多新的理念与思路。本文将对尿生物标记物在原发性肾小球肾炎中的临床意义进行综述。Primary glomerulonephritis, which has complex causes, is a group of diseases characterized by glomerular damage. It can be caused by kidney itself as well as secondary to systemic diseases. The treatment of primary glomerulonephritis includes corticosteroids and immune suppressive agents both of which may lead to severe side effects. How to treat these patients safely and effectively by these drugs is one of the problems nephrologists often face to in their daily work. In recent years, more and more studies showed that urinary biomarkers had potential values in predicting the effect and prognosis of glomerulonephritis, thus can help clinicians choose an effective and safe way and also provide new concepts and ideas in clinical work. This article will review the clinical significance of urinary biomarkers in patients with primary glomerulonephritis.

关 键 词：原发性肾小球肾炎 生物标记物 激素 免疫抑制剂 预后 

分 类 号：R692.31[医药卫生—泌尿科学]