T型分叉管内牛顿与非牛顿血流特性对比分析  

Analysis of Newtonian and Non-Newtonian Blood Flow in T-Bifurcation Artery

作　　者：章德发[1] 刘莹[1] 史皓良 张智亮[2] 

机构地区：[1]南昌大学机电工程学院,江西南昌330031 [2]南昌大学第一附属医院心血管科,江西南昌330006

出　　处：《中国医学物理学杂志》2015年第2期198-202,共5页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(51165031)

摘　　要：目的:动脉粥样硬化是引起心血管疾病的重要因素。结合临床心血管相关病例,从交叉学科的角度分析了入口血流速度和血液粘度对T型分叉管内血流分布的影响,以探索T型分叉管内血流分布与动脉粥样硬化形成的关系,为临床诊断与治疗提供一定的指导。方法:根据血液流动的粘性不可压缩Navier-Stokes方程,运用Auto CAD建立了T型分叉血管的几何模型,并采用计算流体力学方法 (Computational Fluid Dynamics,CFD)对分叉管内血液流动进行数值模拟,分析不同初始条件下分叉管内血流分布对动脉粥样硬化形成的影响。结果:数值模拟结果显示,与牛顿血液粘度模型相比,非牛顿血液粘度模型下血流分布较合理;分叉管的壁面切应力明显大于主血管,而分叉管的壁面压力却小于主血管,表明分叉处管壁受到高切应力与低壁面压力的共同作用,血管内壁易疲劳损伤,促进动脉粥样硬化的产生;这与分叉处附近A与B处存在较大面积的低速涡流区相符合,为动脉粥样硬化的形成提供有利条件。结论:通过对T型分叉管血液流体动力学的数值模拟,表明入口血流速度和血液粘度在动脉粥样硬化形成过程中具有重要作用。另外,数值模拟结果与临床检测结果一致,为进一步研究心血管疾病的机理提供一种有效、可靠的研究方法。Objective Atherosclerosis is an important factor to cause cardiovascular diseases. Combined with clinical pertinent cardiovascular cases, to analyze the influence of the distribution of blood flow on atherosclerosis formation in T-bifurcation artery from local hemodynamics, mainly including entrance velocity of blood flow and blood viscosity model from multidisci- plinary subject angles, to research the relationship between the distribution of blood flow and the formation of atherosclerosis, and provide some guidance for clinical diagnosis and treatment. Methods According to the viscous incompressible Navier-Stokes equation of blood flow, the geometry model ofT-bifurcation artery was created by AutoCAD. The computational fluid dynamics methods was applied to simulate the blood flow in T-bifurcation artery and the influence of diverse initial condi- tions of blood flow on atherosclerosis formation. Results The numerical simulation results show, comparing with the Newtonian blood model, the blood flow distribution of Non-Newtonian blood model is reasonable. The wall shear stress of the bifurcated vessel is significantly larger than the main vessel, but the wall pressure of bifurcation vessel is less than the main vessel. It shows that this vascular wall under high stress and low wall pressure, causing the blood vessel wall injury very easy, promoting atherosclerosis formation. There is larger vortex blood flow area near A and B of T-bifurcation artery, and providing favorable conditions for the formation ofatherosclerosis, Conclusion Though the numerical simulation ofhemodynamics in T-bifurcation artery, the entrance velocity of blood flow and the blood viscosity model play an important role in the process of atherosclerosis. The numerical simulation results agree with the clinical results further study of the mechanism of cardiovascular diseases. of CT. And it provides a reliable and availability method for the further study of the mechanism of cardiovascular diseases.

关 键 词：动脉粥样硬化 T型分叉血管 计算流体力学 非牛顿血液 

分 类 号：Q66[生物学—生物物理学]