中国四川汉族人群乙醛脱氢酶2基因多态性与颈动脉内膜中膜厚度的关系  

The Relationship between the Aldehyde Dehydrogenase 2 Gene Polymorphism and Carotid Intima-media Thickness in the Han Population of Sichuan, China

作　　者：马孝湘[1,2] 陈晓平[2] 程幼夫[1] 何霞[3] 帅平[1] 杨雁华[1] 肖仙[1] 刘玉萍[1] 

机构地区：[1]四川省医学科学院.四川省人民医院健康管理中心,成都610072 [2]四川大学华西医院心脏内科 [3]四川省医学科学院.四川省人民医院药物基因组实验室

出　　处：《华西医学》2015年第3期401-405,共5页West China Medical Journal

基　　金：四川省干部保健科研课题(川干研2013-213)~~

摘　　要：目的研究乙醛脱氢酶2(ALDH2)基因多态性与与颈动脉内膜中层厚度(IMT)的关系。方法从2013年4月-2014年2月体检的310例颈动脉IMT增厚者(IMT增厚组)和280例颈动脉IMT正常的健康者(对照组)外周血中提取DNA,采用DNA微阵列芯片法检测两组ALDH2基因多态性。结果 IMT增厚组与对照组基因型分布均符合Hardy-Weinberg平衡。与正常对照组相比,颈动脉IMT增厚组ALDH2基因AA/AG基因型和A等位基因频率(分别为67.4%、37.9%)明显高于对照组(分别为41.1%、22.3%),差异有统计学意义(P<0.001);logistic回归显示ALDH2基因多态性与颈动脉IMT增厚相关[OR=2.381,95%CI(1.356,4.213),P=0.004]。结论 ALDH2基因多态性与中国四川汉族人群颈动脉IMT增厚相关,ALDH2基因多态性可能在颈动脉IMT增厚遗传易感性方面具有重要作用。Objective To investigate the relationship between the aldehyde dehydrogenase 2 gene（ALDH2） polymorphism and carotid intima-media thickness（IMT）. Methods From April 2013 to February 2014, 310 cases of carotid IMT thickening（IMT thickening group） from the physical examination center were included in the study and 280 cases of normal carotid IMT were regarded as controls. DNA was extracted from peripheral blood. ALDH2 gene polymorphism was detected by DNA microarray method. Results Genotype distributions had no deviation from Hardy-Weinberg equilibrium in both groups. Compared with controls, the frequency of AA/AG genotypes（67.4%, 41.1%; P 〈 0.01） and the frequency of A allele（37.9%, 22.3%; P 〈 0.001） of ALDH2 gene were apparently increased in the subjects of IMT thickening group. There was a signifficant dif erence in the frequency distribution of genotype and allele in ALDH2 between the two groups. The logistic analysis showed that the ALDH2 gene polymorphism was associated with the increased carotid IMT [OR=2.381, 95%CI（1.356, 4.213）, P=0.004]. Conclusions The ALDH2 gene polymorphism is correlated with the increased carotid IMT in the Han population of China Sichuan. The ALDH2 gene polymorphism may play an important role in genetic susceptibility of increased carotid IMT.

关 键 词：乙醛脱氢酶2 基因多态性 颈动脉内膜中层厚度 

分 类 号：R543.4[医药卫生—心血管疾病]