pH敏感药用载体mPEG-HZ-Chol的合成及胶束的制备  

Synthesis of pH-sensitive m PEG-HZ-Chol and preparation of self-assembly of paclitaxel polymeric micelles

作　　者：李红霞[1] 陆燕[1] 张思颖[1] 常月红[1] 

机构地区：[1]江苏大学药学院,江苏镇江212013

出　　处：《华西药学杂志》2015年第2期131-133,共3页West China Journal of Pharmaceutical Sciences

基　　金：江苏省自然科学基金青年基金项目(BK20130526);江苏大学学生科研立项(12A486)

摘　　要：目的设计合成p H敏感药用载体材料m PEG2000-HZ-Chol,并考察其p H敏感性。方法以胆固醇为原料,在酯化、酰肼化后,与m PEG醛通过p H敏感的腙键连接,合成目标物并进行p H敏感性的研究。使用红外光谱、核磁共振、薄层色谱等方法对其进行表征,评价其体外p H敏感性。结果与结论所合成的材料具有p H敏感性,p H敏感值为5.5。OBJECTIVE To synthesize a pH - sensitive medicinal carrier mPEG2000 - HZ - Chol, and evaluate the pH sensitivity. METHODS The target compounds were synthesized from cholesterol through esterification and hydrazide and hydrazone,then connected with mPEG aldelyde by hydrazone bond which is pH - sensitive. The pH sensitivity of target compounds were studied. The chemical structures of products were charaeterized by methods such as NF - IR,m HNMR and TLC. The in vitro pH sensitivity was evaluated by UV spectrophotometry. RESULTS and CONCLUSION The mPEG2000 - HZ - Chol shows significant pH sensitivity, and the pH - sensi- tive value was 5.5.

关 键 词：聚乙二醇 胆固醇 药用载体 PH敏感性 合成 胶束 

分 类 号：R94[医药卫生—药剂学]