聚乙二醇化艾塞那肽对肥胖恒河猴的减肥作用  

Anti-obesity effect of Pegylated exenatide in obese rhesus monkeys

作　　者：潘虹[1] 杨遵远 汤春贵 徐敏 曾文 龚立[1] 

机构地区：[1]四川抗菌素工业研究所,四川成都610052 [2]四川普莱美行之生物科技有限公司,四川成都610041 [3]雅安市人民医院,四川雅安625000 [4]派格生物医药苏州有限公司,江苏苏州215000

出　　处：《华西药学杂志》2015年第2期175-178,共4页West China Journal of Pharmaceutical Sciences

基　　金：国家科技支撑计划项目(2012BAI23B08;2014BAI03B01)

摘　　要：目的研究聚乙二醇化艾塞那肽(PB199)长期给药对肥胖恒河猴的减肥作用。方法一个月内每周一次sc PB199,观察其对肥胖恒河猴体重、腹部脂肪体积、摄食量、血糖和血脂等肥胖相关指标的影响。结果给药一个月后,模型对照组动物的体重与给药前比增加1.34%,3、6μg·kg-1PB199组猴的体重与给药前比分别降低5.14%、5.68%,较模型对照组的差异显著(P<0.05)。与给药前比,3、6μg·kg-1PB199、艾塞那肽、奥利司他组猴的腹部皮下脂肪体积下降率分别为42.1%、42.2%、39.0%、41.8%,腹腔内脂肪的体积下降率分别为20.8%、20.8%、16.9%、20.5%,各组较模型对照组的差异显著(P<0.05)。结论一个月连续给药PB199对肥胖恒河猴具有显著的减肥作用。OBJECTIVE To explore the anti -obesity effect of long- term administration of pegylated exenatide （PB199） in obese rhesus monkeys. METHODS The body weight, abdominal fat volume, food intake, blood glucose and lipid levels were measured before and after PB199 was administrated weekly for 1 month. RESULTS After the administration,the body weight of modal group increased 1.34% ,3 μg·kg^-1 and 6 μg·kg^-1 while PB199 groups significant decreased 5. 14% and 5.68%, respectively, compared with the control group. Compared with pre - expose, the abdominal subcutaneous fat volume of 3 μg·kg^-1 and 6 μg·kg^-1 PB199, Exenatide and Orlistat groups decreased 42.1% ,42.2% , 39.0% and 41.8% , respectively, intra - abdominal fat volume of the model group, 3 μg·kg^-1 and 6 μg·kg^-1 PB199, Exenatide and Orlistat groups significant decrease 20.8% ,20.8% , 16.9% and 20.5% , compared with the control group. CONCLUSION PB199 has effect of anti - obesity in obese rhesus monkeys after administrated for 1 month.

关 键 词：聚乙二醇化艾塞那肽 减肥 恒河猴 药效学 摄食量 奥利司他 

分 类 号：R96[医药卫生—药理学]