4种抗精神病药治疗精神分裂症急性期的最小成本分析  

Cost-minimization Analysis of 4 Kinds of Antipsychotic Drugs in the Treatment of Acute Phase of Schizophrenia

作　　者：蒋立新[1] 褚留杰[1] 张瑞岭[1] 

机构地区：[1]新乡医学院第二附属医院,河南新乡453002

出　　处：《中国药房》2015年第11期1445-1447,共3页China Pharmacy

基　　金：河南省卫生厅卫生政策研究课题(No.YWZY201348)

摘　　要：目的:比较4种抗精神病药治疗精神分裂症急性期的经济学效果。方法:采用回顾性研究方法,选出以利培酮(A组)、喹硫平(B组)、奥氮平(C组)和阿立哌唑(D组)单一治疗的住院精神分裂症急性期患者病历共194份,运用药物经济学方法进行评价。结果:A、B、C、D组的有效率、住院天数和不良反应发生率比较差异均无统计学意义(P>0.05),急性期治疗总成本分别为7 648.11、8 996.51、9 228.02、9 419.93元。结论:在精神分裂症急性期,利培酮治疗最具经济性。OBJECTIVE：To compare the economic effect of 4 kinds of antipsychotic drugs in the treatment of acute phase of schizophrenia. METHODS：194 hospitalized patients with acute phase of schizophrenia were divided into group A（risperidone group）,group B（quetiapine group）,group C（olanzapine group）and group D（aripiprazole group）by retrospective study,and the pharmacoeconomics were evaluated. RESULTS：There was no statistical significance in total effective,hospitalization days and the incidence of ADR among 4 groups（P〉0.05）. The total costs of drug treatment in the acute phase for 4 groups were 7 648.11,8996.51,9 228.02 and 9 419.93 yuan,respectively. CONCLUSIONS：In the treatment of the acute phase of acute phase of schizophrenia,the most economical drug is risperidone.

关 键 词：精神分裂症急性期 利培酮 喹硫平 奥氮平 阿立哌唑 最小成本分析 

分 类 号：R971.41[医药卫生—药品] R956[医药卫生—药学]