我院151例严重的药品不良反应报告分析  

Analysis of 151 Cases of Serious Adverse Drug Reaction Reports in Our Hospital

作　　者：尚丹婷 李洵[1] 陈美玲[1] 许惠英[1] 朱红球[1] 

机构地区：[1]广东省人民医院/广东省医学科学院药学部,广州510120

出　　处：《中国药房》2015年第11期1514-1516,共3页China Pharmacy

摘　　要：目的:了解我院严重药品不良反应(ADR)发生的特点及规律,为促进临床安全、合理用药提供参考。方法:对我院2010-2013年上报的151例严重的ADR报告进行统计、分析。结果:发生2例疑似ADR死亡病例;男性和老年患者严重的ADR发生率较高,分别占53.64%和44.37%;口服给药引起的严重的ADR占47.68%,静脉给药占45.03%;在涉及的所有药品中,抗微生物药和抗肿瘤药各占18.54%,循环系统药占14.57%;严重的ADR累及器官/系统以血液系统最多,占22.16%。结论:临床应关注严重的ADR涉及药品及其引起机体损害的临床表现,加强用药监测,减轻或避免严重的ADR的发生;药品生产企业应加强产品上市后安全性研究及ADR跟踪监测,完善产品说明书,增加相关安全性信息。OBJECTIVE：To explore the characteristics and regular patterns of serious adverse drug reactions（ADR）and provide reference for the safety drug use in clinic. METHODS：151 reports of serious ADR in our hospital from 2010 to 2013 were statistically analysis. RESULTS：2 cases were suspected as death;the incidences of ADR in male and elderly patients were high,accounting for 53.64% and 44.37%,respectively;serious ADR caused by oral and intravenous administration were respectively47.68% and 45.03%. In all the involving drugs,the ratio of anti-microbial drugs and anti-tumor drugs was 18.54% for both,and the drugs of circulatory system was 14.57%. Blood system had large proportion and the most serious ADR involving organs or systems（22.16%）. CONCLUSIONS：Clinic should pay attention to the serious ADR drugs and their clinical manifestations,strengthen drug monitoring;It is suggested that the manufacturers should strengthen the safety research and ADR tracking and monitoring after the products listing,improve the instructions of products and increase relevant security information,reduce or avoid serious ADR and promote rational drug use in clinic.

关 键 词：严重的不良反应 合理用药 死亡 老年患者 

分 类 号：R969.3[医药卫生—药理学] R978.1[医药卫生—药学]