临床药师合理用药有效干预对药品不良反应发生率的影响  

Analysis of the Effects of Clinical Pharmacists Intervention of Rational Drug Use on the Incidence of Adverse Drug Reaction

作　　者：陈瑞祥[1] 刘兴才[1] 花萍[1] 

机构地区：[1]南通大学医学院附属东台市人民医院药学科,江苏东台224200

出　　处：《中国药房》2015年第11期1517-1520,共4页China Pharmacy

摘　　要：目的:探讨临床药师通过合理用药有效干预对药品不良反应(ADR)发生率的影响。方法:采用回顾性调查分析的方法,对我院2010-2013年临床合理用药有效干预前后收集到的325例ADR报告(其中干预前167例,干预后158例)进行统计、分析。结果:干预前167例ADR监测报告中,年龄<10岁儿童29例(17.37%),≥70岁老年人33例(19.76%),静脉滴注148例(88.62%),抗感染药95例(56.89%),中药注射剂21例(12.57%),药师报告14例(8.38%);干预后158例ADR监测报告中,年龄<10岁儿童36例(22.79%),≥70岁老年人29例(18.35%),静脉滴注126例(79.75%),抗感染药67例(42.41%),中药注射剂32例(20.25%),药师报告39例(24.68%)。给药途径、抗感染药应用等方面更趋合理,药师上报率有所提高。结论:我院临床药师通过处方审核管理系统及相关措施的有效干预,在促进临床合理用药、降低ADR的发生率上取得了一定的成效。OBJECTIVE：To investigate the effects of intervention of clinical pharmacists＇ rational drug use on the incidence of adverse drug reaction（ADR）. METHODS：Retrospective analysis was conducted to statistically analysis the 325 ADR reports（167cases before intervention,158 cases after intervention）in our hospital from 2010 to 2013. RESULTS：Among the 167 ADR reports before intervention,there were 29 cases of children ender the age of 10（17.37%）,33 cases of the elder of 70 and older（19.76%）,148 cases of intravenous injection（88.62%）,95 cases of anti-infective drugs（56.89%）,21 cases of TCM injection（12.57%）and 14 cases of pharmacists＇ reports（8.38%）. Among the 158 ADR reports after intervention,there were 36 cases of children under the age of 10（22.79%）,29 cases of elder of 70 and older（18.35%）,126 cases of intravenous injection（79.75%）,67 cases of anti-infective drugs（42.41%）,32 cases of TCM preparation（20.25%）and 39 cases of pharmacists＇ reports（24.68%）. Some aspects tended to be more reasonable,such as administration route and antibacterials,etc,and the reporting rate of pharmacist was improved. CONCLUSIONS：Rational drug use has been improved and incidence of ADR has decreased due to the prescription audit management system and effective intervention measures in our hospital.

关 键 词：合理用药 临床药师 有效干预 药品不良反应 发生率 

分 类 号：R969.3[医药卫生—药理学]