HCV患者年龄、抗体和HCV RNA与血清分型的关系  

Study of the Relationship Between the Age of Patients with HCV,Antibodies to HCV RNA and the Viral Serotypes

作　　者：杨锡琴[1] 修冰水[1] 冯晓燕[1] 王国华[1] 陈坤[1] 宋晓国[1] 朱翠侠[1] 张贺秋[1] 

机构地区：[1]军事医学科学院基础医学研究所,北京100850

出　　处：《临床输血与检验》2015年第2期100-102,共3页Journal of Clinical Transfusion and Laboratory Medicine

基　　金："十二五"重大传染病专项研究课题(No.2012ZX10002003-004-009)资助

摘　　要：目的采用建立的丙型肝炎病毒（HCV）血清分型技术,探讨HCV患者年龄、抗体（S/CO）和HCV RNA与血清分型的关系。方法收集HCV慢性感染患者血清200例,定量检测HCV RNA、抗-HCV,同时进行血清分型,并进行统计分析。结果 200例慢性丙肝患者的血清抗-HCV抗体均为阳性,S/CO〉3.5,HCV RNA滴度在1.12×103~9.29×107 copies/ml。其中血清1型102例,2型58例,混合型2例,分型率为81.00%。采用Student t检验分析年龄、抗体S/CO、HCV RNA与分型之间的关系,t值分别为1.842 9,0.446 7,1.778 2,P均〉0.05,无统计学意义。结论 HCV患者年龄、抗体（S/CO）和HCV RNA滴度对血清分型结果没有影响。Objective To establish the hepatitis C virus（HCV）serotyping techniques to explore the relationship between the age of patients infected with HCV,antibodies（S/CO）,HCV RNA and serotypes.Methods Two hundred cases of serum samples of HCV chronic infection were collected,including 101 cases of male,99 cases of female with the average age of 44 years.Quantitative detection of HCV RNA,anti-HCV test,and serotyping were used for the investigation,and the Student t test was used for statistical analysis.Results Two hundred cases of anti-HCV antibodies of patients with chronic hepatitis C were positive（S/CO〉3.5）,HCV RNA titers were from 1.12×103 to 9.29×107 copies/ml.In 200 serum samples of chronic hepatitis C patients,102 cases showed the type 1,58 cases exhibited type 2,and a mixed genotype was noted in 2cases.The sensitivity reached up to 81.00%.In comparison of the factors between age,antibody S/CO,HCV RNA,and serotypes,no statistical significance was seen（t values were 1.842 9,0.446 7,1.778 2,P〉0.05.Conclusions There is no obvious association of the age of patients with HCV,antibody titers（S/CO）,and HCV RNA with HCV serotypes.

关 键 词：丙型肝炎病毒 血清型 HCV RNA 抗体(S/CO) 

分 类 号：R512.63[医药卫生—内科学] R446.11[医药卫生—临床医学]