Ⅱ型糖尿病伴非酒精性脂肪肝病患者炎症因子与内皮功能的改变  

The change of endothelial function and inflammatory cytokinesin in type 2 diabetes mellitus and non-alcoholic fatty liver disease

作　　者：黄虹[1] 杨丕坚[1] 李舒敏[1] 吕以培[1] 

机构地区：[1]钦州市第二人民医院内分泌科,广西钦州535000

出　　处：《西部医学》2015年第4期529-530,533,共3页Medical Journal of West China

摘　　要：目的探讨Ⅱ型糖尿病伴非酒精性脂肪肝病(NAFLD)患者炎症因子、内皮功能的改变。方法 28例单纯Ⅱ型糖尿病患者(DM组)和30例Ⅱ型糖尿病伴NAFLD患者(NAFLD组)以及30例健康体检者(对照组)进行临床、生化指标及肱动脉血流介导的内皮依赖性舒张功能(FMD)各项检查,比较3组临床、生化各项指标及FMD。结果Ⅱ型糖尿病伴NAFLD组TNF-α、IL-6、hs-CRP、HOMA-IR及ET-1均高于Ⅱ型糖尿病组及对照组(P<0.05),FMD、NO较Ⅱ型糖尿病组及对照组降低。经逐步线性回归分析显示FMD水平和hs-CRP、NAFLD、HOMA-IR呈显著负相关。结论Ⅱ型糖尿病伴NAFLD患者与炎症、血管内皮功能障碍密切相关,Ⅱ型糖尿病伴NAFLD患者需及早进行血管内皮功能障碍干预,预防动脉粥样硬化的发生。Objective To study the change of endothelial function and inflammatory cytokinesin in type 2 diabetes mellitus and non-alcoholic fatty liver disease（NAFLD）. Methods 28 diabetic patients without NAFLD （DM group）, and 30 diabetic patients with NAFLD （NAFLD group） and 30 healthy volunteers （control group）were enrolled. Clinical indicators,biochemical indicators,and flow-mediated dilatation（FMD）of brachial artery were examined. The clinical indicators,biochemical indicators,and FMD of brachial artery were compared in the three groups. Results The NAFLD group showed significantly lower FMD, NO than DM group and control groups（P〈0.05）. The NAFLD group showed that the TNF-α,IL-6,hs-CRP,HOMA-IR,ET-1 were higher than that of DM group and control groups （P〈0.05）. The liner stepwise regression analysis showed that the FMD was negatively correlated with hs-CRP, HOMA-IR and NAFLD. Conclusion type 2 diabetes mellitus and non-alcoholic fatty liver disease is closely related to inflammation, vascular endothelial dysfunction. These patients need early endothelial dysfunction intervention to prevent the atherosclerosis.

关 键 词：Ⅱ型糖尿病 非酒精性脂肪肝 内皮功能障碍 炎症 动脉粥样硬化 

分 类 号：R587.1[医药卫生—内分泌]