左乙拉西坦单药治疗小儿癫痫78例临床观察  

Observation on clinical effect of Levetiracetam used in 78 children with epilepsy

作　　者：倪晓琳[1] 胡晓[2] 瞿浩[2] 李世容[2] 王建怡[3] 

机构地区：[1]遵义医学院小儿内科,563003 [2]贵州省人民医院神经内科,550002 [3]贵州省人民医院小儿内科,550002

出　　处：《中外女性健康研究》2015年第2期6-7,14,共3页Women＇s Health Research

基　　金：本文为贵州省科技厅攻关项目[黔科合SY字（2012）3143号]：贵州省科技厅项目[黔科合J字（2011）2281号]

摘　　要：目的：观察左乙拉西坦（levetiracetam，Lev）治疗癫痫患儿的临床疗效和安全性。方法：对2010年1月至2013年6月我院收治的78例小儿癫痫患者进行Lev单药治疗，采用自身对照随访研究。Lev起始剂量10mg/kg·d，一天2次口服，每周增加5~10mg/kg·d，目标剂量为30~40mg/kg·d，维持剂量35mg/kg·d。门诊复查及电话随访，观察其发作频率和不良反应。结果：78例患儿中，完全控制发作59例，良好3例，有效8例，总有效率89.7%。治疗前后发作频率差异有统计学意义（P＜0.05）。不良反应以头痛、嗜睡、厌食、情绪激动、行为异常为主，对症治疗或达到维持剂量后自行消失。结论：Lev作为一种新型抗癫痫药物，单药治疗小儿癫痫作用广，有良好疗效及安全性，值得在临床治疗中推广和应用。Objective：To evaluate the clinical efficacy and safety of levetiracetam monotherapy in children with epilepsy. Methods：78 children patients with epilepsy who were diagnosed in our hospital from January 2010 and June 2013, were treated by Levetiracetam, then follow-up visited. Dose of LEV was initially 10mg/kg·d, twice a day, every week the dose increased 5~10mg/kg·d, maintained at 30~40mg/kg·d, and finally was increased to 35mg/kg·d. Followed up to observe the seizure frequency and adverse reactions. Results：Among the 78 cases, complete seizure control was found in 59 cases, excellence in 3 cases, effective in 8 cases, the total effective rate was 89.7%.There was significant difference of seizure frequency before and after therapy（P〈0.05）.The major side effects observed were headache, lethargy, anxiety, abnormal behavior etc,and the symptoms were disappeared within the treatment. Conclusions：LEV as a new type of antiepileptic drugs, is efficacious of children with epilepsy, and has few adverse reactions and should be wildly applied to epileptic children.

关 键 词：左乙拉西坦 癫痫 儿童 

分 类 号：R971.6[医药卫生—药品]