线粒体转录终止因子蛋白家族在线粒体基因表达中的调节作用  

Regulatory Roles of Mitochondrial Transcription Termination Factor(MTERF) Family Proteins in Mitochondrial Gene Expression

作　　者：熊伟[1,2,3] 余敏[3] 左绍远[1,2] 

机构地区：[1]大理学院基础医学院生物化学与分子生物学教研室,云南大理671000 [2]云南省昆虫生物医药研发重点实验室,云南大理671000 [3]云南大学生命科学学院生物化学与分子生物学实验室,昆明650091

出　　处：《中国生物化学与分子生物学报》2015年第3期223-231,共9页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金项目(No.31260276);云南省教育厅科学研究重点项目(No.2014Z126);大理学院博士科研启动基金项目(No.BSKY2012018);云南省大学生创新创业计划项目(No.201402)资助~~

摘　　要：线粒体转录终止因子(mitochondrial transcription termination factor,MTERF)是一类由核基因编码且高度保守的线粒体DNA结合单体蛋白质,广泛存在于后生动物和植物中.近年来,MTERF蛋白家族对线粒体基因表达调控的作用及其机制研究获得大量成果,对阐明线粒体基因组的表达调控机制及研究人类线粒体疾病等方面有重要的意义.本文综述MTERF蛋白家族4个成员的性质,及其对线粒体DNA复制、转录和翻译的影响,探讨MTERF蛋白家族各成员调控线粒体基因表达的可能机制,展望其对线粒体疾病研究的应用前景.Mitochondrial transcription termination factors （MTERFs） are a group of highly conserved mtDNA-binding monomeric proteins that are encoded by nuclear genes. MTERFs are widely found in metazoans and plants. In recent years, a lot of remarkable progress about the regulatory roles of MTERFs in mitochondrial gene expression has been made. These research achievements are very significant for elucidating expression and regulation of mitochondrial genome, and for studying human mitochondrial diseases. This article summarized the characteristics of four MTERF family members and their different regulation roles in mtDNA replication, transcription, and translation. The regulatory mechanism of each MTERF family member in mitochondrial gene expression and their application prospects for research of human mitochondrial diseases was also discussed.

关 键 词：线粒体转录终止因子 基因表达 调节作用 

分 类 号：Q71[生物学—分子生物学]