电容耦合电场配合低频脉冲电磁场治疗去势大鼠骨质疏松的实验研究  

Preliminary study on the effect of capacitive-coupled pulsed electric field combined with low-frequency pulsed electromagnetic fields for osteoporosis

作　　者：王正兴[1] 田学隆[1] 

机构地区：[1]重庆大学生物工程学院,重庆400030

出　　处：《中国康复医学杂志》2015年第3期231-236,共6页Chinese Journal of Rehabilitation Medicine

基　　金：重庆市科技攻关计划重点项目(CSTC2010AA5049)

摘　　要：目的:探讨电容耦合电场(CCPEF)配合低频脉冲电磁场(PEMFs)对去势大鼠骨质疏松的治疗效果。方法:选取3月龄的雌性SD大鼠50只,体重(250±20)g,随机分成5组:空白组,对照组,低频脉冲电磁场组(PEMFs),电容耦合电场组(CCPEF),电容耦合电场配合低频脉冲电磁场组(PEMFs+CCPEF)。空白组进行假手术,其余4组制作动物模型。模型完成后4周进行治疗,空白组与对照组:不进行任何刺激;PEMFs组暴露在低频脉冲磁场(15Hz,0.4m T)中,8h/d,连续治疗12周;CCPEF组的刺激频率为1.5MHz,强度为20Vpp,每天1次,每次20min,每周5次,连续治疗11周。PEMFs+CCPEF组:同时进行PEMFs和CCPEF的暴露治疗。结果:从尿液和血液、子宫系数、生物力学性能数据看出,PEMFs组、CCPEF组、PEMFs+CCPEF组分别与对照组相比较,均具有显著性差异(P<0.05);PEMFs+CCPEF组与PEMFs组、CCPEF组比较,除了Ca、P、ALP参数数据外,其他参数均具有显著性变化(P<0.05)。结论:电容耦合电场配合低频脉冲电磁场对骨质疏松具有良好的疗效且比其单一的治疗方式效果更佳。Objective： To investigate the treatment effect of capacitive-coupled pulsed electric field （CCPEF） combined with low-frequency pulsed electromagnetic fields （PEMFs） on osteoporosis in ovariectomized rats. Method： Fifty female 3 month aged SD rats, weighing （250±20）g, were chosen and divided into five groups： Blank group, Contrast group, PEMFs group, CCPEF group, PEMFs＋CCPEF group. Blank group received sham operation, and other groups were established into are animal models. Four weeks after modeling, the treatments started： Blank group and Contrast group without any stimulation; PEMFs group were exposed in PEMFs （15Hz, 0.4mT）, 8h/d, for 12 weeks; CCPEF group were placed in CCPEF （1.SMHz, 20Vpp）, 20min/d, 5 times a week, for 11 weeks; PEMFs＋CCPEF group exposured in PEMFs and CCPEF simultaneously. Result： From the data of urine and blood, uterine factor and biomechanical performance, PEMFs, CCPEF and PEMFs＋CCPEF groups compared with Contrast group, all had significant differences （P〈0.05）; PEMFs＋ CCPEF group compared with PEMFs group and CCPEF group, in addition to parameter data of Ca, P, ALP, other parameters all had significant changes （P 〈 0.05）. Conclusion： The effect of PEMFs combined with CCPEF on osteoporosis was better than the single treatment.

关 键 词：电容耦合电场 低频脉冲电磁场 骨质疏松症 生物力学性能 

分 类 号：R580[医药卫生—内分泌] R454.1[医药卫生—内科学]