复方茵丹汤治疗急性淤胆型肝炎30例临床观察  

Treatment of Acute Cholestatic Hepatitis by Compound Yindan Decoction: a Clinical Observation

作　　者：孙凤霞[1,2] 王建美[1,3] 刘龙[1] 

机构地区：[1]首都医科大学附属北京地坛医院肝病科,北京100015 [2]首都医科大学附属北京中医医院感染科,北京100010 [3]天津市北辰医院内科,天津300400

出　　处：《中国中西医结合杂志》2015年第3期310-313,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：北京市中医药科技基金资助项目(No.JJ2011-16);国家中医药管理局第三批全国优秀中医临床人才研修项目(No.国中医药人教函〔2012〕148号);北京市卫生系统高层次卫生技术人才培养计划(No.2013-3-024)

摘　　要：目的观察西医综合治疗基础上加用复方茵丹汤治疗急性淤胆型肝炎的临床疗效。方法采用随机对照研究方法,将符合纳入标准的60例急性淤胆型肝炎的患者,随机分为治疗组(西医综合治疗联合复方茵丹汤)和对照组(西医综合治疗),每组30例。观察两组治疗前后中医症候积分以及肝功能水平[总胆红素(total bilirubin,TBIL),直接胆红素(direct bilirubin,DBIL),碱性磷酸酶(alkaline phosphatase,ALP),谷氨酰转肽酶(glutamyl transpeptidase,GGT)及胆汁酸(total biliary acid,TBA)]的变化。结果与本组治疗前比较,治疗组与对照组患者治疗1周末、4周末症状总积分均降低(P<0.05),治疗4周后TBIL、DBIL、ALP、GGT、TBA均降低(P<0.01)。与对照组同期比较,治疗组治疗1周末症状总积分明显降低(P<0.05),治疗组治疗1、2周末TBIL、DBIL、ALP、GGT、TBA降低(P<0.05)。与对照组比较,治疗组患者TBIL、DBIL下降至正常5倍以内的平均时间明显缩短(P<0.05)。结论复方茵丹汤治疗急性淤胆型肝炎,可以明显改善临床症状,降低TBIL、DBIL、ALP、GGT及TBA,明显改善胆汁淤积,促进病情恢复。Objective To observe the clinical efficacy of comprehensive Western medical treat- ment plus Compound Yindan Decoction （CYD） in treatment of acute cholestatic hepatitis （ACH）. Meth- ods Using randomized controlled study, 60 ACH patients in line with inclusive criteria were randomly assigned to the treatment group （treated by comprehensive Western medical treatment plus CYD） and the control group （treated by comprehensive Western medical treatment alone）, 30 in each group. Scores for symptoms and levels of liver functions [total bilirubin （TBIL）, direct bilirubin （DBIL）, alkaline phosphatase （ALP）, glutamyl transpeptidase （GGT）, total biliary acid （TBA）] were observed before and after treatment. Results Compared with before treatment in the same group, total scores for symp- toms decreased in the treatment group and the control group at the end of the 1 st and the 4th week after treatment （all P〈0.05）. Compared with the control group, total scores for symptoms decreased in the treatment group at the end of the 1 st week （P 〈0.05）. Compared with before treatment, serum levels of TBIL, DBIL, ALP, GGT, and TBA all decreased in the two groups at the end of the 4th week after treat- ment （P 〈0.01 ）. Compared with the control group, serum levels of TBIL, DBIL, ALP, GGT, and TBA all decreased in the treatment group at the end of the 1st and the 2nd week after treatment （P 〈0.05）. Com- pared with the control group, the average time for TBIL and DBIL decreasing to the level less than five times the normal value was significantly shorter in the treatment group （P 〈0.05）. Conclusion CYD could significantly improve clinical symptoms of ACH patients, decrease serum levels of TBIL and DBIL,reduce serum levels of ALP, GGT, and TBA, obviously improve cholestasis, and promote the recovery.

关 键 词：复方茵丹汤 黄疸 急性淤胆型肝炎 

分 类 号：R259[医药卫生—中西医结合]