Th17细胞及其相关因子与Graves病并发胰岛素抵抗的关系研究  

Relationship between Th17,related factors and Graves disease complicated by insulin resistance

作　　者：凌俊辉[1] 黄志威[1] 蔡斯俏[1] 石峰[1] 赖必发[1] 

机构地区：[1]广东省梅州市人民医院,514023

出　　处：《中国现代医药杂志》2015年第3期14-17,共4页Modern Medicine Journal of China

基　　金：广东省梅州市科技计划项目(编号:2014B06)

摘　　要：目的探讨Th17细胞及其相关因子与Graves病(GD)并发胰岛素抵抗(IR)的关系。方法用流式细胞仪检测30例GD并发IR患者、30例单纯GD患者及20例健康人外周血Th17细胞数量,采用ELISA法测定IL-6、IL-17、IL-23的水平,并与FT3、FT4、TSH作相关性分析。结果 GD并发IR患者外周血和单纯GD患者的Th17细胞数量均高于正常对照组(P<0.05),而GD并发IR患者的IL-6和IL-17水平显著高于单纯GD患者、正常对照组(P<0.05),但IL-23含量与单纯GD患者、正常对照组无统计学差异(P>0.05),并且IL-6和IL-17水平与FT3、FT4呈正相关(P<0.05)。结论 IL-6、IL-17的变化可能与Graves病并发胰岛素抵抗的发病机理有关。Objective To explore the correlation between Th17, related factors and Graves disease （GD） complicated by insulin resistance （IR）. Methods The quantity of ThlT, the serum level of IL-6, IL-17, IL-23 were measured in 30 patients with GD and IR, 30 patients with GD and 20 normal people. Meanwhile, the correlation between serum IL-6, IL-17, IL-23 and FT3, FT4, TSH in those patients were analyzed. Results The serum levels of IL-6 and IL-17 were significantly higher in GD and IR group than GD group and control group （P〈0.05）. Whereas there was no significantly difference in the levels of IL-23 among GD and IR group, GD group and control group （P〉0.05）. The levels of IL-6 and IL-17 had a significantly positive correlation with FT3, FT4 （P〈0.05）. Conclusion The changes of IL-6 and IL-17 may involve in the pathogenesis of Graves disease.

关 键 词：GRAVES病 胰岛素抵抗 TH17 相关因子 

分 类 号：R581.1[医药卫生—内分泌]