右归饮治疗激素性股骨头坏死的研究  

Research on treating and preventing femoral head necrosis induced by hormone with Yougui Yin

作　　者：宋才渊 沈兴潮 吕帅杰 鲍航行[2] 金红婷[1,3] 肖鲁伟[1,3] 童培建[1,2,3] 

机构地区：[1]浙江中医药大学,杭州310053 [2]浙江省中医院,杭州310006 [3]浙江省骨伤研究所,杭州310053

出　　处：《中华中医药杂志》2015年第4期1204-1207,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：浙江省中医药重点研究计划项目(No.2011ZZ005)~~

摘　　要：目的:观察右归饮治疗SD大鼠激素性股骨头的疗效,探讨其药物作用机制及指导临床实践。方法:取30只SD大鼠随机分成3组:正常对照组、右归饮组、激素模型组;右归饮组和激素模型组采用大肠杆菌内毒素腹腔联合甲泼尼松龙琥珀酸钠进行造模,正常对照组在给予等量0.9%氯化钠溶液注射。右归饮组在造模的同时,每天右归饮灌胃,连续8周,激素模型组和正常对照组予等容积0.9%氯化钠溶液代替。各种动物在第8周末进行行为学检测,并取血测定血脂和血凝指标。结果:右归饮组能降低血脂中甘油三酯、总胆固醇、低密度脂蛋白及血凝PT和APTT等相关指标(P<0.01),在高密度脂蛋白方面无作用。右归饮能改善大鼠一般情况和行为学中旷场试验、垂直得分、抓力等指标(P<0.05)。结论:右归饮对于激素性股骨头坏死具有预防和治疗作用。Objective： To observe the curative effect of Yougui Yin on SD rat with femoral head necrosis induced by hormone,and to explore its mechanism so as to guide the clinical practice.Methods： 30 SD rats were randomly divided into three groups such as control group,Yougui Yin group and model group.Rats in Yougui Yin group and model group received intraperitoneal injection with Escherichia coli endotoxin combined with methylprednisolone sodium succinate to establish rat models of femoral head necrosis,and rats in control group received intraperitoneal injection with the same amount of saline solution.Rats in Yougui Yin group received gavage administration with Yougui Yin for 8 weeks,and rats in control and model group received gavage administration with the same amount of saline solution.Animal behavior detections were carried out on the 8th week,and blood was sampled to test the blood fat and coagulation indicators.Results： Yougui Yin could decrease triglyceride,total cholesterol,low density lipoprotein,PT,APTT and so on significantly（P〈0.01）,while the effect of Yougui Yin on high density lipoprotein cholesterol was not significant.Yougui Yin could improve the general condition and behavioral manifestation in open field test,vertical score,grip and so on significantly（P〈0.05）.Conclusion： The comparative study in blood fat,coagulation indicators and behaviors of rats in the three groups further confirmed that Yougui Yin could treat and prevent femoral head necrosis induced by hormone.

关 键 词：右归饮 股骨头坏死 血脂 血凝 运动活动 

分 类 号：R274.9[医药卫生—中西医结合]