地西泮与氟马西尼合用对兔定量药物脑电图δ频段功率百分比的影响  

Effects of diazepam on the percentage of δ-band power of quantitative pharmaco-electroencephalogram in rabbits

作　　者：王卿[1,2] 赵健[3] 李玲玲[3] 戴体俊[4] 

机构地区：[1]徐州医学院研究生学院,江苏徐州221004 [2]徐州医学院学报编辑部,江苏徐州221004 [3]徐州医学院临床医学系,江苏徐州221004 [4]徐州医学院麻醉药理学教研室,江苏徐州221004

出　　处：《中国临床药理学杂志》2015年第7期540-543,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(30872432;30471657;39970715);江苏省社会发展科技计划基金资助项目(BS 200054);徐州医学院药学院研究生科研创新计划基金资助项目(2010YKYCX011)

摘　　要：目的观察地西泮对兔定量药物脑电图（QPEEG）δ频段功率百分比的影响及其与苯二氮受体的关系。方法 36只家兔随机分为6组（n=6）,均静脉注射。空白组用0.9%氯化钠1 m L·kg-1,3个剂量地西泮组：0.12,0.25,0.50 mg·kg-1地西泮,氟马西尼组用氟马西尼0.1 mg·kg-1,合用组先注射0.1 mg·kg-1氟马西尼5min后,再注射0.5 mg·kg-1地西泮。用数字脑电地形图仪分别计算给药前及给药后各时间点兔各脑区QPEEGδ频段功率百分比。结果与给药前比较,0.25,0.50 mg·kg-1地西泮组各脑区δ频段功率百分比在0.5~30.0 min增加,且与地西泮剂量呈正相关;合用组的δ频段功率百分比明显低于同时点的0.50mg·kg-1地西泮组。结论地西泮以剂量依赖方式增加兔QPEEGδ频段功率百分比且由苯二氮受体介导,提示δ频段可能成为反映镇静催眠程度的指标。Objective To observe the effects of diazepam on the percen-tage of δ -band power of quantitative pharmaco -electroencephalogram （ QPEEG ） in rabbits and the relation with benzodiazepine receptor.Methods Thirty-six healthy rabbits were randomly divided into 6 groups （each n=6）,where rabbits in each group were intravenously injected with 1 mL· kg-1 0.9%NaCl （blank group）, 0.12 mg· kg-1 , 0.25 mg· kg-1 or 0.50 mg· kg-1 diazepam groups, 0.1 mg· kg-1 flumazenil group and 0.1 mg· kg-1 flumazenil ＋0.5 mg· kg-1 diazepam （ combined group ）.Then a digital EEG system was adopted to record the changes of QPEEG in eight encepha-lic regions before and after injection at each time point.Results The per-centage of δband power in eight encephalic regions of 0.25, 0.50 mg· kg-1 diazepam groups are noted increase within 0.5 to 30 min.The change of the percentage of δ band power has a positive correlation with diazepam dose.Compared with the 0.5 mg· kg-1 diazepam group,the percentage of δ-band power in combined group was lower at same time point.Conclusion Diazepam increases the percentage ofδ-band power of QPEEG in the way of dose dependence in rabbits.It indicates that benzodiazepine receptor mediates the effect of diazepam and the percentage of δ-band power may become an index that reflects the degree of sedation and hypnosis.

关 键 词：地西泮 氟马西尼 定量药物脑电图 镇静催眠程度 Δ频段 

分 类 号：R971.2[医药卫生—药品] R965.1[医药卫生—药学]