复方金沙利胆颗粒药效学及急性毒性研究  

Experimental study on pharmacodynamics and acute toxicity of compound Jinshalidan Granules

作　　者：易爱玲 邹福生[1] 魏盈盈[2] 陈炜[2] 杜光[2] 

机构地区：[1]武汉市黄陂区人民医院药剂科,武汉430300 [2]华中科技大学附属同济医院药学部,武汉430030

出　　处：《中国临床药理学杂志》2015年第7期560-562,572,共4页The Chinese Journal of Clinical Pharmacology

基　　金：武汉市临床医学科研基金资助项目(WZ14Z21武卫生计生办[2014]92号)

摘　　要：目的研究复方金沙利胆颗粒的利胆、抗炎作用及其急性毒性。方法用大鼠胆总管引流法观察复方金沙利胆颗粒的利胆作用及二甲苯致小鼠耳廓肿胀模型评价药物的抗炎作用,并评价药物的急性毒性,测定小鼠的最大耐受剂量。结果与正常对照组相比,3个剂量组的复方金沙利胆颗粒能显著增加大鼠的胆汁流量,明显改善二甲苯所致小鼠耳肿胀程度。急性毒性实验连续观察14 d,无动物死亡,肉眼观察未见明显毒性反应。复方金沙利胆颗粒小鼠灌胃给药的最大耐受剂量为244.8 g·kg-1(生药)。结论复方金沙利胆颗粒具有显著的利胆、抗炎作用,其急性毒性小,初步证明是安全的。Objective To investigate the cholagogic and anti -infla-mmatory effects and acute toxicity of Jinshalidan Granules.Methods The cholagogic effect of Jinshalidan Granules was observed and deter-mined by common bile duct drainage in mouse .The acute inflammatory models was established by xylene -induced ear edema to research the inflammatory effects of Jinshalidan Granules.The acute toxicity and the maximum tolerated dose in mice were also studied.Results Compared with the normal control group , the bile secretion for the mouse and the degree of swelling of mice ear induced by xylene were significantly improvemed in all the 3 different dosages of Jinshalidan Granules.After 14 days, continuous observation ,no mouse was found dead and no signifi-cant toxicity occurred by naked eyes.The maximum tolerated dose of Compound Jinshalidan Granules is 244.8 g · kg -1 （ crude drug ）.Conclusion Compound Jinshalidan Granules have obviously effects on the increased the bile secretion and anti -inflammatory ,it is has very low acute toxicity in mice and preliminary proven to be safe .

关 键 词：复方金沙利胆颗粒 药效学 利胆 抗炎 急性毒性 

分 类 号：R285.5[医药卫生—中药学] R976[医药卫生—中医学]