扶正逐毒丸制剂大鼠长期毒性实验研究  

Experimental study on chronic toxicity of Fuzheng Detoxification Pill in rats

作　　者：高晓东 李雪萍[2] 徐春茂 刘宝录 王晓蕾[3] 管国倩 李建银[3] 

机构地区：[1]甘肃省疾病预防与控制中心,兰州730000 [2]甘肃省医学科学研究院,兰州730050 [3]兰州大学药学院,兰州730000

出　　处：《中国临床药理学杂志》2015年第7期563-565,共3页The Chinese Journal of Clinical Pharmacology

基　　金：2013年中央补助地方重大公共卫生项目--甘肃省中医治疗艾滋病基金资助项目(甘财社(2013)146号文件)

摘　　要：目的研究大鼠长期口服扶正逐毒丸所产生的毒性反应及其程度。方法按照成人每日用量,实验大鼠分为高、中、低3个剂量(56.0,18.7,3.3g·kg-1·d-1)组和对照组。连续灌胃给药90 d,对一般情况进行观察,对体重、进食量进行称量比较,对血液学指标、血液生化指标、尿常规进行检测,对脏器进行病理学检查和脏器系数比较。结果实验组与对照组比较,大鼠的一般状况、行为活动、进食量、体重变化、外周血象、尿常规指标、血液生化指标、脏器系数以及病理组织学等,差异均无统计学意义。结论扶正逐毒丸大鼠长期毒性实验未见不良反应,提示临床拟用剂量安全。Objective To observe the long term toxicity and degree in rats after giving Fuzheng Detoxification Pill by intragastric administra-tion.Methods According to the adult daily dose , the rats were divided into four groups：high dose （56.0 g· kg -1 · d-1 ）, middle dose （18.7 g· kg -1 · d -1 ） , and low dose test groups （ 3.3 g · kg-1 · d-1 ） with Fuzheng Detoxification Pill and control group with 0.9%NaCl.The medi-cation administration teams were gavaged with Fuzheng Detoxification Pill for 90 days.After 90 days, the behavior and general condition of experi-ment rats were observed.The change of weight and food intake of each group were compared.And the indexes of hematology , biochemistry were also measured.Meanwhile , the organ measure by pathology were mea-sured and the index of organ was compared.Results Compared with the control group , there were no significant difference in the outer appearance and behavior , body weight , organ coefficients ,and the inde-xes of hermatology and biochemistry in the test groups.The pathological examination revealed that no obvious pathological changes related to drug toxicity and no delayed toxicity reaction after drug withdrawal.Conclusion Fuzheng Detoxification Pill has no obvious toxicity in rats for long -term administration , which infers that the doses drawn up in clinic will be safe.

关 键 词：扶正逐毒丸 毒性实验 长期毒性 

分 类 号：R285.5[医药卫生—中药学] R977.9[医药卫生—中医学]