MicroRNA-143在肿瘤与心血管等方面的研究状况  

Research status of microRNA-143 in tumor,cardiovascular and other aspects

作　　者：陈思[1] 张荣[1] 

机构地区：[1]哈尔滨医科大学药学院药理学教研室,哈尔滨150086

出　　处：《中国临床药理学杂志》2015年第7期573-576,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81102434)

摘　　要：MicroRNA（miRNA）是一类内源性的长度约20~24个核苷酸的非编码单链的RNA分子,在细胞发育、增殖、凋亡、分化等方面发挥着重要作用。其中,microRNA-143（miR-143）是一种肿瘤抑制性miRNA,它在多种肿瘤中呈低表达,被视为肿瘤抑制因子,miR-143在其他方面的研究也逐渐增多,因此本文对miR-143在肿瘤、心血管、2型糖尿病并发症以及细胞分化等方面的研究情况做一综述。MicroRNA （ miRNA） is derived length of about 20-24 nu-cleotides in non-coding single-stranded RNA molecules within a class , in terms of cell growth, proliferation, apoptosis, differentiation plays an important role.Wherein the microRNA -143 is a tumor inhibitory miRNA, which showed low expression in a variety of tumors , is regarded as tumor suppressor.With further research , the study of miR -143 in other areas is gradually increasing , so this aspect of miR -143 in cancer , cardiovascular , type 2 diabetes and other complications , and cell differentiation studies the case reviewed.

关 键 词：microRNA-143 肿瘤 心血管 2型糖尿病并发症 细胞分化 

分 类 号：R968[医药卫生—药理学] R363.25[医药卫生—药学]