妊娠期糖尿病患者血清内脂素与瘦素水平的变化及其与孕前体质指数的相关性研究  

Changes of serum visfatin and leptinin gestational diabetes and their relationships with progestation body mass index

作　　者：丁俊蓉[1] 周益伟 徐静[1] 陈艳[1] 胡欣[1] 

机构地区：[1]潍坊市妇幼保健院内分泌科,261011 [2]潍坊护理职业学院

出　　处：《中国糖尿病杂志》2015年第4期310-312,共3页Chinese Journal of Diabetes

摘　　要：目的探讨GDM患者血清内脂素、瘦素(Leptin)水平变化的意义,并探讨两者与孕前BMI的相关性。方法采用ELISA检测内脂素和Leptin的水平,并记录患者孕前体重、身高,计算BMI。结果血清内脂素与FIns、胰岛素抵抗指数(HOMA-IR)呈正相关(r=0.471、0.624,P<0.05),Leptin与孕前BMI、HOMA-IR呈正相关(r=0.492、0.605,P<0.05)。结论 GDM患者存在IR,孕前BMI升高与妊娠期Leptin升高相关,内脂素、Leptin可影响GDM患者IR的程度。Objective To investigate the changes of serum visfatin and leptin levels in GDM and their relationships with progestation body mass index（BMI）. Methods The levels of visfatin and leptin were measured by enzyme‐linked immunosorbent assay （ELISA）. The weight and height before pregnancy were recorded ,and BMI was calculated as kg/m^2. Results Serum visfatin was postively associated with fasting insulin （FIns） and HOMA‐IR（r=0.471 ,0.624 ,P〈0.05）.Serum leptin was positively associated with progestation BMI and HOMA‐IR（r= 0.492 ,0.605 ,respectively ,P〈 0.05）. Conclusion Insulin resistance status exists in patients with GDM. The increase of BMI before pregnancy has relationship with the increase of serum leptin during pregnacy.The levels of leptin and visfatin may affect the extent of IR in patients w ith GDM.

关 键 词：糖尿病 妊娠 内脂素 瘦素 体质指数 

分 类 号：R714.256[医药卫生—妇产科学]