丙基硫氧嘧啶(PTU)对妊娠合并甲状腺功能亢进孕妇甲状腺功能及妊娠结局的影响  

The Effect of propylthiouracil on the thyroid function and pregnancy outcome of pregnant women with hyperthyroidism

作　　者：叶苑 

机构地区：[1]广东省河源市和平县人民医院内科,517200

出　　处：《齐齐哈尔医学院学报》2015年第7期947-949,共3页Journal of Qiqihar Medical University

摘　　要：目的探讨丙基硫氧嘧啶(PTU)对妊娠合并甲状腺功能亢进孕妇甲状腺功能及妊娠结局的影响。方法选择2010年4月至2014年4月我院收治的150例妊娠合并甲状腺功能亢进孕妇作为研究对象,按是否服用PTU治疗分为实验组和对照组,实验组采用PTU治疗,对照组拒绝服用或治疗中自行停药,比较两组孕妇甲状腺功能、妊娠结局、并发症以及围生儿结局。结果实验组TT4、FT3、TT3、TSH以及FT4水平均较对照组低,差异有统计学意义(P<0.05)。实验组足月产率高于对照组,而流产率、早产率和剖宫产率低于对照组,差异有统计学意义(P<0.05)。实验组心力衰竭、妊娠高血压和重度子痫发生率均低于对照组,差异有统计学意义(P<0.05)。实验组新生儿甲亢、低体重儿、胎儿窘迫和转入NICU率均低于对照组,差异有统计学意义(P<0.05)。两组畸形发生率比较差异无统计学意义(P>0.05)。结论 PTU可降低甲状腺功能亢进孕妇的甲状腺功能水平,改善围生儿结局和妊娠结局,安全性良好。Objective This study was to evaluate the effect of propylthiouracil on the thyroid function andpregnancyoutcomeofpregnantwomenwithhyperthyroidism.Methods 150casesofpregnantwomenwith hyperthyroidism during April 2010 and April 2014 in our hospital were chosen as research subject.They were divided into control group and experimental group according to whether take PTU.Patients in experimental group were treated with PTU.Thyroid function, pregnancy outcome, occurrence of complications and perinatal outcome of the two groups were compared.Results The concentration of TT4, FT3, TT3, TSH and FT4 of experimental group were lower than those of control group, the differences were statistically significant （P 〈0.05）.Partus matures rate of experimental group was higher than that of control group, but rate of abortion, premature delivery and cesarean section of experimental group was lower than control group, the differences were statistically significant （P〈0.05）.The incidence of heart failure, pregnancy induced hypertension and preeclampsia of experimental group were lower than control group, the differences were statistically significant （ P 〈0.05）. Neonatal hyperthyroidism, low birth weight, fetal distress and transferred to the NICU rate of experimental group were lower than control group, the difference were statistically significant （P〈0.05）.Deformity rate of the two group had no significant difference （〉0.05）.Conclusions PTU can reduce the thyroid function of pregnant women with hyperthyroidism, improve the perinatal outcome and the outcome of pregnancy.

关 键 词：丙基硫氧嘧啶 妊娠结局 甲状腺功能亢进 

分 类 号：R581.1[医药卫生—内分泌]