外周血促肾上腺皮质激素释放激素浓度与先兆早产的相关性及其影响因素  

Correlation between Concentration of Corticotropin Releasing Hormone and Threatened Premature Labor in Peripheral Blood and Influencing Factors

作　　者：徐漫飞[1] 周洋[1] 赵岩[1] 

机构地区：[1]中国医科大学附属盛京医院妇产科,沈阳110004

出　　处：《中国医科大学学报》2015年第4期342-345,共4页Journal of China Medical University

摘　　要：目的检测先兆早产患者外周血促肾上腺皮质激素释放激素（CRH）浓度,探讨其浓度与先兆早产症状的相关性及影响其浓度的因素,以探讨CRH浓度作为预测早产指标的可行性。方法选取先兆早产住院孕妇及不足月非先兆早产原因住院孕妇共45例,其中先兆早产组（孕28~36周）22例,对照组（孕28~36周、无先兆早产症状的孕妇）23例。采每位受试对象抗凝外周血5 m L,分离血浆,采用ELISA法测定CRH浓度。结果先兆早产组孕妇外周血CRH浓度与对照组孕妇相比显著升高（P〈0.01）。先兆早产组与对照组的新生儿出生Apgar评分（1和5 min）均〉7分,且2组比较新生儿出生Apgar评分无统计学差异（P〉0.05）。先兆早产组与对照组比较,宫颈Bishop评分无统计学差异（P〉0.05）,先兆早产组中CRH浓度与宫颈Bishop评分无明显关系（P〉0.05）。先兆早产组与对照组中,双胎者与单胎者相比,胎膜早破者与非胎膜早破者相比,CRH浓度的差异均有统计学意义（均P〈0.05）。结论血浆CRH浓度明显升高是先兆早产的显著指标。血浆CRH浓度不影响新生儿出生状态和宫颈成熟度,但受妊娠胎儿数影响,且与胎膜早破密切相关。血浆CRH浓度有望成为预测先兆早产的指标,但其影响因素较多,应在分析其影响因素后进一步研究其预测定量值。Objective To detect the concentration of corticotropin releasing hormone （CRH） in peripheral blood in patients with threatened pre- term labor and investigate the correlation between CRH concentration and threatened preterm labor symptoms, so as to explore the feasibility of CRH concentration as a premature prediction index. Methods A total of 45 hospitalized patients were enrolled including 22 patients with threatened preterm labor （ pregnancy 28-36 weeks ） and 23 controls （pregnancy 28-36 weeks, no premonitory symptoms of preterm labor）. The 5 mL fresh pe- ripheral venous blood samples were obtained from all the 45 subjects, and the plasma was separated. The ELISA method was used to determinate the concentration of CRH. Results The concentration of CRH in peripheral blood in patients with threatened preterm labor was significantly higher than in the control group, there was a statistically significant difference （P 〈 0.01 ）. The Apgar scores （ 1 rain and 5 rain） of the threatened premature la- bor group and the control group were both more than 7 points, and there was no statistical difference in the newborn Apgar score between the two groups （P 〉 0.05）. There was no statistical difference in the cervical Bishop score between the threatened preterm labor group and the control group （P 〉 0.05 ）, and there was no obvious relationship between the CRH concentration and the cervical Bishop score in the threatened preterm labor group （ P 〉 0.05 ）. In both groups, there were statistically significant differences in CRH concentration between the twins and the singleton, and be- tween the patients with premature rupture of membranes （PROM） and those without PROM （all P 〈 0.05 ）. Conclusion Increased plasma CRH concentration is a significant index of threatened premature labor. Plasma CRH concentration does not affect the neonatal birth condition and the cer- vical maturity. The plasma concentration of CRH is affected by pregnancy number of fetuses, and is closely related

关 键 词：先兆早产 促肾上腺皮质激素释放激素 血浆浓度 ELISA法 早产预测指标 

分 类 号：R714.21[医药卫生—妇产科学]