温度敏感型凝胶基质的研究进展  

Progress in research of temperature-sensitive gel matrix

作　　者：沈晶晶[1,2] 刘宏[1] 熊康萍 

机构地区：[1]广州军区武汉总医院,武汉430070 [2]湖北中医药大学,武汉430065

出　　处：《中国新药杂志》2015年第7期800-803,817,共5页Chinese Journal of New Drugs

摘　　要：通过检索近年来国内外有关温敏凝胶基质的应用、成胶机制及优缺点等方面的文献报道进行归纳和总结。目前已有多种天然及合成水性聚合物用于温敏凝胶基质,主要包括天然及改性聚合物、聚N-异丙基烯酞胺类聚合物、聚氧乙烯-聚氧丙烯共聚物、交联PLGA嵌段共聚物4大类。温敏凝胶载体基质发展迅速,新型基质具有配方简单、生物相容性好及生物可降解等优点,在生物医学及制药方面得到广泛应用。Objective： To introduce the progress in research of temperature-sensitive gel matrix used as a drug carrier and the development level in its present application. Methods： The reports in the literature at home and abroad were searched and summarized, which described the application of temperature-sensitive gel matrix, ge- lation mechanism, and its advantages and disadvantages. Results： Many natural and synthetic water-soluble poly- mers have been used for temperature-sensitive gel matrix. These polymers include four categories： natural and mod- ified polymers, poly N-isopropyl erie amide polymers, polyoxyethylene-polyoxypropylene copolymers, and crosslinked PLGA copolymers. Conclusion： The temperature-sensitive gel carrier matrix is developing rapidly. New matrixes have advantages such as simple formula, good biocompatibility and biodegradable, which are widely used in biomedical and pharmaceutical areas.

关 键 词：温敏凝胶 基质 成胶机制 

分 类 号：R943[医药卫生—药剂学]